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1. |
Record Nr. |
UNISA996385736803316 |
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Autore |
La Perriè€re Guillaume de <1499-1565.> |
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Titolo |
The theater of fine deuices [[electronic resource] ] : containing an hundred morall emblemes. First penned in French by Guillaume de la Perriere, and translated into English by Thomas Combe |
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Pubbl/distr/stampa |
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London, : Printed by Richard Field, 1614 |
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Descrizione fisica |
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[112] p. : ill. (woodcuts) |
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Altri autori (Persone) |
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CombeThomas <fl. 1593-1614.> |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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A translation of: La theatre des bons engins. |
In verse. |
Signatures: A-G. |
The first leaf is blank. |
Reproduction of the original in the Henry E. Huntington Library and Art Gallery. |
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Sommario/riassunto |
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2. |
Record Nr. |
UNISA996392458203316 |
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Titolo |
By the Lords Iustices and Council. Maurice Eustace Canc. Orrery. Mountrath. Whereas we are given to understand by the informations of many persons well deserving credit [[electronic resource] ] : that of late times there have been sundry unlawful assemblies in many parts of the kingdom . |
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Pubbl/distr/stampa |
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Imprinted at Dublin, : by William Bladen, by special order, anno Dom. 1660 [i.e. 1661] |
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Descrizione fisica |
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Altri autori (Persone) |
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EustaceMaurice, Sir, <ca. 1590-1661.> |
MountrathCharles Coote, Earl of, <ca. 1610-1661.> |
OrreryRoger Boyle, Earl of, <1621-1679.> |
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Soggetti |
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Ireland History 1660-1688 Early works to 1800 |
Ireland Politics and government 17th century Early works to 1800 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from caption and first lines of text. |
Dates are given according to Lady Day dating. |
At end of text: Given at the Council-Chamber in Dublin the 22. day of Ianuary 1660. |
Steele notation: credit, as publique; Arms 177. |
Reproduction of original in the British Library. |
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Sommario/riassunto |
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3. |
Record Nr. |
UNINA9910292955603321 |
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Autore |
Willhelm, Sidney M. |
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Titolo |
Urban zoning and land-use theory / Sidney M. Willhelm |
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Pubbl/distr/stampa |
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New York, : The free press of Glencoe, c1962 |
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Descrizione fisica |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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4. |
Record Nr. |
UNINA9910830641003321 |
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Titolo |
Analysis of drug impurities [[electronic resource] /] / edited by Richard J. Smith and Michael L. Webb |
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Pubbl/distr/stampa |
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Oxford ; ; Ames, Iowa, : Blackwell, 2007 |
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ISBN |
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1-281-32024-2 |
9786611320249 |
0-470-98874-6 |
0-470-99422-3 |
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Descrizione fisica |
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1 online resource (290 p.) |
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Collana |
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Analytical chemistry series |
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Altri autori (Persone) |
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SmithRichard J |
WebbMichael L |
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Disciplina |
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Soggetti |
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Drugs - Analysis |
Materia medica |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Analysis of Drug Impurities; Contents; Preface; List of contributors; 1 Organic impurities in drug substance: origin, control, and measurement; 1.1 Introduction; 1.2 Origin of impurities; 1.2.1 Process impurities; 1.2.2 Degradation impurities; 1.2.3 Contamination impurities; 1.2.4 Other impurities; 1.3 Control of drug substance impurities; 1.3.1 Control of residual solvents; 1.3.2 Control of synthetic impurities; 1.3.3 Control of impurities in biological and botanical products; 1.3.4 Purification processes; 1.3.5 Control of impurities from packaging; 1.3.6 Control of contamination impurities |
1.3.7 Control of degradants on stability1.4 Measurement of drug substance impurities; 1.4.1 HPLC; 1.4.2 GC; 1.4.3 CE; 1.4.4 General considerations; 1.5 Conclusions; Disclaimer; References; 2 Organic impurities in drug products: origin, control and measurement; 2.1 Introduction; 2.2 Analytical methodology; 2.3 Drug-excipient compatibility experimental design; 2.4 Degradation mechanisms; 2.5 Excipients' role in drug product destabilisation; 2.6 Processing as a source of moisture; 2.7 Hydrolysis; 2.8 Oxidation; 2.9 Photolysis; 2.10 Impact of processing on photostability |
2.11 Miscellaneous reactions2.12 Container-closure systems; References; 3 Stereochemical impurities; 3.1 Introduction; 3.2 Separation techniques: direct resolution; 3.2.1 HPLC using CSPs; 3.2.2 HPLC using chiral mobile-phase additives; 3.2.3 Capillary electrophoresis using chiral selectors; 3.2.4 Supercritical fluid chromatography using chiral stationary phases; 3.2.5 Gas chromatography using chiral stationary phases; 3.3 Separation techniques: indirect resolution; 3.4 Non-separation techniques; 3.4.1 Chiroptical spectroscopy; 3.4.2 Nuclear magnetic resonance spectroscopy; 3.5 Conclusions |
AcknowledgementsReferences; 4 Low-level measurement of potent toxins; 4.1 Introduction; 4.2 Classes of genotoxic impurity; 4.2.1 Alkylating agents; 4.2.2 Reactive amines; 4.2.3 Fused tricyclics; 4.2.4 Substituted purines and pyrimidines; 4.2.5 Hydroperoxides; 4.3 The analytical challenge of genetic; 4.4 Gas chromatography; 4.4.1 Sample introduction techniques; 4.4.2 Detectors; 4.5 High-performance liquid chromatography; 4.5.1 Separation modes; 4.5.2 Detection techniques; 4.6 Supercritical fluid chromatography; 4.7 Thin-layer chromatography; 4.8 Sample pre-concentration |
4.8.1 Liquid-liquid extraction4.8.2 Solid-phase extraction; 4.8.3 Solid-phase microextraction; 4.8.4 Liquid-phase microextraction; 4.9 Other techniques; 4.9.1 Electrochemical measurements; 4.9.2 Derivatisation methods; 4.10 Adapting analytical methods from fields beyond pharmaceuticalsimpurities analysis; 4.10.1 Antineoplastic agents; 4.10.2 Other fields; 4.11 Validation of trace analytical methods; 4.11.1 Sensitivity; 4.11.2 Specificity; 4.11.3 Accuracy; 4.11.4 Solution stability; 4.11.5 Linearity and precision; 4.12 Conclusions; References; 5 A systematic approach to impurity identification |
5.1 Introduction |
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Sommario/riassunto |
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A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative |
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methods.Written for both practic |
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