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1. |
Record Nr. |
UNISA996385030903316 |
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Titolo |
The execution and confession with the behaviour & speeches of Capt. Thomas Walcot, William Hone, and John Rouse [[electronic resource] ] : who according to the sentence pronounced against them at the Old-Bayley, on the 12th instant, were this 20th of July drawn, hanged and quartered, for traytorously conspiring to assassinate and murther the King in his return from New-Market, and the establish'd government to subvert &c. Entred according to order |
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Pubbl/distr/stampa |
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London, : Printed by J. Grantham, 1683 |
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Descrizione fisica |
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Altri autori (Persone) |
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WalcotThomas <d. 1683.> |
HoneWilliam <d. 1683.> |
RouseJohn <d. 1683.> |
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Soggetti |
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Rye House Plot, 1683 |
Executions and executioners - England |
Last words - England |
Great Britain History Charles II, 1660-1685 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Caption title. |
Imprint from colophon. |
All three men were involved in the Rye House Plot. |
Variant edition of Wing E3848 can be found on reel 425:8b, bound with L505C (The last speeches and confessions). |
Reproduction of original in the Huntington Library. |
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Sommario/riassunto |
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2. |
Record Nr. |
UNINA9910674020103321 |
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Autore |
Alonso Juan Carlos |
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Titolo |
Toxin-Antitoxin Systems in Pathogenic Bacteria |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
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Descrizione fisica |
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1 online resource (170 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Bacterial toxin-antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens. |
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