1.

Record Nr.

UNISA996339126903316

Titolo

Oxford handbook of nursing older people

Pubbl/distr/stampa

Oxford, : Oxford University Press, 2009

ISBN

9780199597956

Descrizione fisica

1 online resource (xxxiii, 643 p.) : ill

Collana

Oxford handbooks in nursing Oxford handbook of nursing older people

Disciplina

618.970231

Soggetti

Geriatric nursing

Specialties, Nursing

Adult

Health Services

Patient Care

Age Groups

Health Care Facilities, Manpower, and Services

Therapeutics

Nursing

Health Care

Analytical, Diagnostic and Therapeutic Techniques and Equipment

Persons

Health Occupations

Named Groups

Disciplines and Occupations

Nursing Care

Aged

Geriatric Nursing

Health Services for the Aged

Medicine

Health & Biological Sciences

Geriatrics

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Bibliographic Level Mode of Issuance: Monograph



Sommario/riassunto

Concentrating on the knowledge and skills needed by nurses working with older people, this book is an invaluable source of information for both student and practising nurses. Acting as both a reference guide and support in everyday clinical decision-making, it contains a wealth of guidance and information.

2.

Record Nr.

UNINA9910140188603321

Titolo

Chemistry of bioconjugates : synthesis, characterization, and biomedical applications / / edited by Ravin Narain

Pubbl/distr/stampa

Hoboken, New Jersey : , : Wiley, , 2014

©2014

ISBN

1-118-77637-2

1-118-77588-0

1-118-77640-2

Descrizione fisica

1 online resource (495 p.)

Altri autori (Persone)

NarainRavin

Disciplina

612.1/111

Soggetti

Bioconjugates

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Includes index.

Nota di bibliografia

Includes bibliographical references at the end of each chapters and index.

Nota di contenuto

CHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions

1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent



Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues

2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain

3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES

5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates

5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTS

Sommario/riassunto

This book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available.