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Record Nr. |
UNISA996328039303316 |
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Autore |
Marginson Simon <1951-> |
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Titolo |
The Dream Is Over : The Crisis of Clark Kerr's California Idea of Higher Education / / Simon Marginson |
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Pubbl/distr/stampa |
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University of California Press, 2016 |
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Berkeley, CA : , : University of California Press, , [2016] |
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©2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (xiv, 243 pages) : illustrations |
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Collana |
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The Clark Kerr lectures on the role of higher education in society ; ; 4 |
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Disciplina |
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Soggetti |
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Education, Higher - Philosophy |
Higher education and state - United States |
Public universities and colleges - California |
Education, Higher - California |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references (pages 223-238) and index. |
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Nota di contenuto |
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Frontmatter -- Contents -- List of Figures and Tables -- Preface -- PART ONE. A CITY UPON A HILL: CLARK KERR AND THE CALIFORNIA IDEA OF HIGHER EDUCATION -- 1. An Extraordinary Time -- 2. Clark Kerr -- 3. Clark Kerr and the California Idea -- 4. The Uses of the University -- 5. Martin Trow: Higher Education and Its Growth -- 6. Bob Clark: The Academic Heartland -- 7. Whither the California Idea of Higher Education? -- PART TWO. CROSSING THE WATERS: THE CALIFORNIA IDEA IN THE WORLD -- 8. The Idea Spreads -- 9. Participation without Limit -- 10. The Spread of Science -- 11. The Global Multiversity -- 12. Systems and Stratification -- 13. American Universities in the Global Space -- 14. Enter the Dragon -- 15. Higher Education in China and the United States -- PART THREE. BRINGING IT ALL BACK HOME: THE CALIFORNIA IDEA IN A MORE UNEQUAL AMERICA -- 16. Higher Education after Clark Kerr -- 17. The Impossibility of Public Good -- 18. The Impossibility of Taxation -- 19. Economic and Social Inequality -- 20. Unequal Opportunity -- 21. Higher Education and the Economy -- 22. Higher Education and Society -- Epilogue: |
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After the Dream -- Notes -- References -- Index |
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Sommario/riassunto |
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"The Dream Is Over tells the extraordinary story of the 1960 Master Plan for Higher Education in California, created by visionary University of California President Clark Kerr and his contemporaries. The Master Plan's equality of opportunity policy brought college within reach of millions of American families for the first time and fashioned the world's leading system of public research universities. The California idea became the leading model for higher education across the world and has had great influence in the rapid growth of universities in China and East Asia. Yet remarkably, the political conditions supporting the California idea in California itself have evaporated. Universal access is faltering, public tuition is rising, the great research universities are under growing pressure, and educational participation in California, once the national leader, lags way behind. Can the social values embodied in Kerr's vision be renewed?"--Provided by publisher. |
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2. |
Record Nr. |
UNINA9911020454503321 |
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Titolo |
Small molecule DNA and RNA binders : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.) |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, c2003 |
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ISBN |
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9786610520664 |
9781280520662 |
1280520663 |
9783527605668 |
3527605665 |
9783527601783 |
3527601783 |
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Descrizione fisica |
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1 online resource (756 p.) |
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Altri autori (Persone) |
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DemeunynckM (Martine) |
BaillyChristian |
WilsonW. D (W. David) |
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Disciplina |
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Soggetti |
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DNA-drug interactions |
Molecular biology |
Binding sites (Biochemistry) |
Nucleic acids |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Small Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II) |
2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts |
4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction |
5.2.3.5 Guanine nucleobase modification/oxidation |
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Sommario/riassunto |
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The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end st |
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