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Comprehensive Chromatography in Combination with Mass Spectrometry; Contents; Contributors; Preface; 1. Introduction; 1.1 Two-Dimensional Chromatography-Mass Spectrometry: A 50-Year-Old Combination; 1.2 Shortcomings of One-Dimensional Chromatography; 1.3 Benefits of Two-Dimensional Chromatography; 1.4 Book Content; 1.5 Final Considerations; 2. Multidimensional Gas Chromatography: Theoretical Considerations; 2.1 Symbols; 2.2 One-Dimensional GC; 2.3 Comprehensive GC x GC; 3. Multidimensional Liquid Chromatography: Theoretical Considerations; 3.1 Two-Dimensional LC Techniques |
3.2 Peak Capacity in HPLC: One- and Multidimensional Separations 3.3 Orthogonality in Two-Dimensional LC-LC Systems; 3.4 Sample Dimensionality and Structural Correlations; 3.5 Separation Selectivity and Selection of Phase Systems in Two-Dimensional LC-LC; 3.6 Programmed Elution in Two-Dimensional HPLC; 3.7 Fraction Transfer Modulation in Comprehensive LC x LC: Additional Band Broadening; 3.8 Future Perspectives; 4. History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Gas Chromatography; 4.1 Fundamentals of GC x GC; 4.2 Modulation; 4.3 GC x GC Data Interpretation |
4.4 GC x GC Instrumentation 4.5 Thermal Modulators; 4.6 Comprehensive Two-Dimensional GC Method Optimization; 4.7 Final Remarks; 5. Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography; 5.1 Timing Requirements of GC x GC Modulators; 5.2 Criteria for Evaluating Modulators; 5.3 Forms of Modulation; 5.4 Single-Stage Flow Modulation; 5.5 Two-Stage Flow Modulation; 5.6 Summary of Flow Modulators; 5.7 Brief Comparison to Thermal Modulation; 5.8 Concluding Remarks; 6. Comprehensive Two-Dimensional Gas Chromatography Combined with Mass Spectrometry |
6.1 Instrument Requirements for GC x GC-MS 6.2 Data Processing of GC x GC-TOF MS Results; 6.3 Method Translation in GC x GC-MS; 6.4 GC x MS; 6.5 Conventional and Alternative Modulation Techniques for GC x GC-MS; 6.6 GC x GC-MS Applications; 6.7 Concluding Remarks; 7. Detector Technologies and Applications in Comprehensive Two-Dimensional Gas Chromatography; 7.1 Detection in GC x GC; 7.2 Comments on GC x GC with Mass Spectrometry; 7.3 Flame Ionization Detection in GC x GC; 7.4 Electron Capture Detection in GC x GC; 7.5 Sulfur Chemiluminescence Detection in GC x GC |
7.6 Nitrogen Chemiluminescence Detection in GC x GC 7.7 Atomic Emission Detection in GC x GC; 7.8 Thermionic Detection in GC x GC; 7.9 Flame Photometric Detection in GC x GC; 7.10 Case Study of GC x GC with Selective Detection; 7.11 Dual Detection with GC x GC; 7.12 Conclusions; 8. History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Liquid Chromatography; 8.1 Method Development and Instrumentation; 8.2 Technical Problems in Comprehensive Liquid Chromatography; 8.3 Detection; 8.4 Data Representation; 8.5 Instrumentation |
8.6 Milestones in Comprehensive Liquid Chromatography |