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1. |
Record Nr. |
UNISA996248281003316 |
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Autore |
Haskins Charles Homer <1870-1937.> |
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Titolo |
The rise of universities / / Charles Homer Haskins |
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Pubbl/distr/stampa |
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Ithaca, New York : , : Cornell University Press, , [1965] |
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©1957 |
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ISBN |
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0-8014-7007-2 |
0-8014-7008-0 |
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Descrizione fisica |
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1 online resource (118 pages) |
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Collana |
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Cornell paperbacks ; ; CP-15 |
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Altri autori (Persone) |
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MommsenTheodor Ernst <1905-1958.> |
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Disciplina |
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Soggetti |
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Universities and colleges - History |
Education, Medieval |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Originally given as the Colver lectures in 1923 at Brown University." |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front matter -- PREFATORY NOTE -- CONTENTS -- I. THE EARLIEST UNIVERSITIES -- II. THE MEDIAEVAL PROFESSOR -- III. THE MEDIAEVAL STUDENT -- BIBLIOGRAPHICAL NOTE -- INDEX |
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Sommario/riassunto |
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The origin and nature of the earliest universities are the subjects of this famous and witty set of lectures by the man whom eminent scholars have called "without exaggeration... the soul of the renascence of medieval studies in the United States." Great as the differences are between the earliest universities and those of today, the fact remains, says Professor Haskins, the "the university of the twentieth century is the lineal descendant of medieval Paris and Bologna." In demonstrating this fact, he brings to life the institutions, instruction, professors, and students of the Middle Ages. |
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2. |
Record Nr. |
UNINA9910713664703321 |
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Autore |
Reid Elliott G. |
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Titolo |
Preliminary investigation on boundary layer control by means of suction and pressure with the U.S.A. 27 airfoil / / by E.G. Reid and M.J. Bamber |
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Pubbl/distr/stampa |
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Washington, [D.C.] : , : National Advisory Committee for Aeronautics, , 1928 |
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Descrizione fisica |
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1 online resource (18 pages, 29 unnumbered pages) : illustrations |
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Collana |
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Technical notes / National Advisory Committee for Aeronautics ; ; No. 286 |
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Soggetti |
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Aerofoils |
Boundary layer control |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"May 1928." |
No Federal Depository Library Program (FDLP) item number. |
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Nota di bibliografia |
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Includes bibliographical references (page 18). |
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3. |
Record Nr. |
UNINA9910345960703321 |
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Autore |
Timothy D. Hewitson |
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Titolo |
Novel Therapeutic Targets and Emerging Treatments for Fibrosis |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (162 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs.Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder.This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with |
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how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level. |
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