Immune dysfunction and immunotherapy in heart disease [[electronic resource] /] / edited by Ronald Ross Watson & Douglas F. Larson

• Record Nr.: UNISA996218596003316
• Pubbl/distr/stampa: Oxford, : Blackwell, 2007
• ISBN: 1-281-06941-8; 9786611069414; 0-470-69232-4; 0-470-76651-4
• Descrizione fisica: 1 online resource (323 p.)
• Classificazione: YB 9022
• Altri autori (Persone): WatsonRonald R (Ronald Ross); LarsonDouglas F
• Disciplina: 616.1/207; 616.1207
• Soggetti: Heart - Diseases - Immunological aspects; Heart - Diseases - Immunotherapy; Immunologic diseases - Complications
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Immune Dysfunction and Immunotherapy in Heart Disease; Contents; Contributors; Preface; About the Editors; Part I Immune dysfunction leading to heart disease: induction by physiological changes; 1 Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling; 2 Immune mechanisms in pediatric cardiovascular disease; 3 Heart failure-role of autoimmunity; 4 Immune basis of hypertension in humans; 5 Immune dysregulation: potential mediator metabolic syndrome-induced cardiac remodeling; 6 T helper 2 cell cytokines in remodeling of aortic wall; 7 Effects of TNF-a on cardiac function8 Immunosuppression in promotion of cardiac allograft vasculopathy; 9 Immunotherapy for left ventricular dysfunction after heart transplantation; Part II Immune dysfunction promoting CVD: induction by transplantation drugs; 10 Immunomodulating therapy in chronic heart failure; 11 Statins in atherosclerosis: role of immune regulation; 12 ACE inhibitors as immunomodulators: treatment of cardiovascular disease; 13 Treatment ; of heart failure by anticytokine therapies; Part III Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs14 Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome; 15 Cytokines and T cell-mediated responses in autoimmune myocarditis; 16 Drugs of abuse: accentuation of immunomodulation of viral myocarditis; Part IV Immune dysfunction leading to heart disease: induction by pathogens; 17 Osteopontin: the link between the immune system and cardiac remodeling; 18 Inflammatory immune activation in heart failure patients: therapeutic implications; 26 Role of oral pathogens in the pathogenesis of coronary heart disease27 Myocardial regenerative potential by stem cell transplant; 28 Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases; Index
• Sommario/riassunto: Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantat