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1. |
Record Nr. |
UNINA9910452036803321 |
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Autore |
Parker Barry R |
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Titolo |
The Isaac Newton school of driving [[electronic resource] ] : physics & your car / / Barry Parker |
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Pubbl/distr/stampa |
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Baltimore, MD, : Johns Hopkins University Press, 2003 |
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ISBN |
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Descrizione fisica |
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1 online resource (259 p.) |
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Disciplina |
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Soggetti |
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Mechanics |
Elasticity |
Motion |
Thermodynamics |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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2. |
Record Nr. |
UNINA9910142496903321 |
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Autore |
Ellenberg Susan Smith |
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Titolo |
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets |
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Pubbl/distr/stampa |
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Chichester ; ; Hoboken, NJ, : Wiley, c2002 |
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ISBN |
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1-280-26999-5 |
9786610269990 |
0-470-32228-4 |
0-470-85415-4 |
0-470-85416-2 |
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Descrizione fisica |
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1 online resource (209 p.) |
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Collana |
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Altri autori (Persone) |
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FlemingThomas R |
DeMetsDavid L. <1944-> |
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Disciplina |
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Soggetti |
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Clinical trials |
Medical ethics committees |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Data Monitoring Committees in Clinical Trials A Practical Perspective; Contents; Preface; 1 Introduction; 1.1 Motivation; 1.2 History of data monitoring committees in government-sponsored trials; 1.3 Data monitoring committees in trials sponsored by the pharmaceutical industry; 1.4 Statistical methods for interim monitoring; 1.5 When are data monitoring committees needed?; 1.6 Where we are today; 1.7 Fundamental principles of data monitoring; References; 2 Responsibilities of the data monitoring committee and motivating illustrations; 2.1 Fundamental charges |
2.2 Specific tasks of the data monitoring committee 2.2.1 Initial review; 2.2.1.1 Review of the study protocol; 2.2.1.2 Review of procedures to ensure quality of study conduct; 2.2.2 Evaluating the quality of ongoing study conduct; 2.2.3 Assessing safety and efficacy data; 2.2.3.1 Termination due to favorable benefit-to-risk; 2.2.3.2 Termination due |
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to unfavorable benefit-to-risk; 2.2.3.3 Termination due to inability to answer trial questions; 2.2.3.4 Continuation of ongoing clinical trials; 2.2.3.5 Consideration of the overall picture: primary and secondary analyses |
2.2.3.6 Modifying sample sizes based on ongoing assessment of event rates 2.2.4 Reviewing the final results; 2.3 The data monitoring committee charter; References; 3 Composition of a data monitoring committee; 3.1 Introduction; 3.2 Required areas of expertise; 3.3 Other relevant characteristics of committee members; 3.4 Committee size; 3.5 Selecting the committee chair; 3.6 Responsibility for appointing committee members; 3.7 Representation of other study components on the committee; 3.8 Preparation for service on a committee; References |
4 Independence of the data monitoring committee: avoiding conflicts of interest 4.1 Introduction; 4.2 Rationale for independence; 4.3 Financial independence; 4.3.1 Sponsors; 4.3.2 Academic investigators; 4.4 Intellectual independence; 4.5 Emotional conflicts; 4.6 Individuals without conflicts; References; 5 Confidentiality issues relating to the data monitoring committee; 5.1 Rationale; 5.2 Limits of confidentiality; 5.2.1 Interim analysis reports; 5.2.2 Access to aggregate data on efficacy and safety outcomes; 5.2.3 The steering committee and maintaining confidentiality |
5.2.4 Settings and procedures allowing broader unblinding 5.2.5 Some illustrations of broader unblinding; 5.2.6 Indirect challenges to confidentiality; 5.3 The need for the data monitoring committee to review unblinded data; References; 6 Data monitoring committee meetings; 6.1 Introduction; 6.2 Specific objectives and timing of meetings; 6.2.1 Organizational meeting; 6.2.2 Early safety/trial integrity reviews; 6.2.3 Formal interim efficacy analyses; 6.2.4 End-of-trial debriefing; 6.3 Preparation of meeting reports; 6.4 Format for meetings; 6.4.1 The closed session; 6.4.2 The open session |
6.4.3 The final closed session |
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Sommario/riassunto |
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There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities.* Provides a practical overview of data monitoring in clinical trials.* |
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3. |
Record Nr. |
UNISA996210786403316 |
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Autore |
Anderson Kym |
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Titolo |
Which winegrape varieties are grown where? : a global empirical picture / / Kym Anderson, with the assistance of Nanda R. Aryal [[electronic resource]] |
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Pubbl/distr/stampa |
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Adelaide : , : The University of Adelaide Press, , 2013 |
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Descrizione fisica |
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1 online resource (xxv, 670 pages) : digital, PDF file(s) |
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Disciplina |
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Soggetti |
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Grapes - Varieties |
Wine and wine making |
Wine industry |
Viticulture |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from publisher's bibliographic system (viewed on 27 May 2016). |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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This new database charts exactly what varieties are grown in which regions around the world. Since the data sets are based on two broad census periods, in 2000 and 2010, readers can also follow major planting trends around the world during the first decade of this new century. This colossal trawl makes it the perfect complement to last year's publication of Wine Grapes by the doughty Robinson, Harding and Vouillamoz. |
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4. |
Record Nr. |
UNINA9910796525803321 |
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Titolo |
The legacies of Bernard Smith : essays on Australian art, history and cultural politics / / edited by Jaynie Anderson, Christopher R. Marshall and Andrew Yip |
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Pubbl/distr/stampa |
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Australia : , : Power Publications : , : Art Gallery NSW, , 2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (xi, 370 pages) : illustrations |
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Disciplina |
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Soggetti |
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Art appreciation - Australia |
Art and society - Australia |
Art - Political aspects - Australia |
Art critics - Australia |
Art historians - Australia |
Festschriften - Australia |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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