Microenvironments in haemopoietic and lymphoid differentiation [[electronic resource] /] / [Ruth Porter and Julie Whelan, editors]

• Record Nr.: UNISA996206959203316
• Pubbl/distr/stampa: London, : Pitman; Summit, N.J., : Distributed in North America by CIBA Pharmaceutical Co., 1981
• ISBN: 0-470-72066-2; 1-280-78395-8; 9786613694348; 0-470-71835-8
• Descrizione fisica: 1 online resource (362 p.)
• Collana: Ciba Foundation symposium ; ; 84 (new ser.)
• Altri autori (Persone): PorterRuth; WhelanJulie
• Disciplina: 596/.01/13
• Soggetti: Blood cells; Cell differentiation
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Microenvironments in haemopoietic and lymphoid differentiation; Contents; Introduction: signals, receptors and repertoire in haemopoietic differentiation; Haemopoiesis in mammalian bone marrow; Discussion; Self-renewing haemopoietic progenitor cells and the factors controlling proliferation and differentiation; Discussion; Haemopoietic microenvironments in vitro: ultrastructural aspects; Discussion; Regulation and localization of lymphocyte production in the bone marrow; Discussion; Environmental factors in haemopoietic failure in humans; Discussion; Mapping cell surface antigen expression on haemopoietic progenitor cells using monoclonal antibodiesDiscussion; Lymphoid differentiation in vitro; Discussion; Microanatomy of the thymus: its relationship to T cell differentiation; Discussion; Expression and function of major histocompatibility complex antigens in the developing thymus: studies on normal and nude mice; Discussion; The human thymic microenvironment; Discussion; Cellular and molecular signals in T cell ; differentiation; Discussion; General discussion: tolerance and diversification of the T cell repertoire; Histophysiology of follicular structures and germinal centres in relation to B cell differentiationDiscussion; The role of germinal centres in the generation of immunological memory; Discussion; Antigen-presenting cells, including Langerhans cells, veiled cells and interdigitating cells; Discussion; Differentiation of function among antigen-presenting cells; Discussion; Final general discussion T cell subsets and T cell function; Decision-making in development; Chairman's summing-up; Index of contributors; Subject index