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Record Nr. |
UNISA996205854103316 |
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Titolo |
Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd |
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Pubbl/distr/stampa |
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Weinheim ; ; New York, : VCH, c1996 |
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ISBN |
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1-281-84266-4 |
9786611842666 |
3-527-61499-0 |
3-527-61498-2 |
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Descrizione fisica |
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1 online resource (466 p.) |
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Collana |
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Methods and principles in medicinal chemistry ; ; v. 4 |
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Altri autori (Persone) |
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PliškaVladimir |
TestaBernard |
WaterbeemdHan van de |
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Disciplina |
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Soggetti |
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Drug lipophilicity |
Toxicology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method |
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 Thermodynamics of van der Waals and Hydrophobic Interactions; 3.1 |
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