Ciba Foundation Symposium, jointly with Co-ordinating Committee for Symposia on Drug Action, on Enzymes and Drug Action [[electronic resource] /] / editor for the Co-ordinating Committee, J.L. Mongar ; editor for the Ciba Foundation, A.V.S. de Reuck

• Record Nr.: UNISA996201262403316
• Pubbl/distr/stampa: Boston, : Little, Brown, 1962
• ISBN: 1-280-76875-4; 9786613679529; 0-470-71925-7; 0-470-71676-2
• Descrizione fisica: 1 online resource (581 p.)
• Collana: Ciba Foundation symposium
• Altri autori (Persone): MongarJ. L; De ReuckAnthony V. S
• Disciplina: 612.0151
• Soggetti: Enzymes; Drugs - Physiological effect; Drugs - Metabolism
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: ENZYMES AND DRUG ACTION; CONTENTS; Wellcome Building Sessions; Session 1: Enzymes as Primary Points of Drug Action; Chairman's introduction; Inhibition of acetylcholinesterase; Discussion; Carbonic anhydrase inhibition and physiological function; Discussion; Session 2: Active Transport; Pinocytosis; Discussion; Possible mechanisms of active transport; Discussion; Effects of drugs on active transport; Discussion; Session 3: Multiple Mechanisms; I. Insulin; The explanation of the action of insulin on sugar permeability at molecular level; Action of insulin on metabolic reactions; Discussion; II. DigitalisAction of cardiac glycosides on ionic movements; Digitalis: action on metabolism and the contractile system; Discussion; III. Central Nervous System Depressants; Action of barbiturates upon respiratory enzymes; Appraising enzymic actions of central depressants by examining cerebral tissues; Discussion; Session 4: Receptors; Relation between enzymes and cholinergic receptors; Discussion; ; Induction of receptors; Discussion; Session 5: Altered Drug Metabolism; Chairman's introduction; Adaptive enzymes in animals; Discussion; Drug tolerance; Discussion; The genetics of drug sensitivity with special reference to suxamethoniumDiscussion; Session 6: Drug Metabolism: Subcellular Aspects; Drug metabolism-subcellular mechanisms; Discussion; Cellular injury by drugs; Protection against cellular injury by drugs; Discussion; Panel Discussion; Ciba Foundation Sessions on Drug-Enzyme Interaction at the Molecular Level; Session 1: Enzymes; Introduction: Enzymes; Models of active centres: acetylcholine; Active transport; Mode of action of insulin; Limitations of enzymes as models; Session 2: Receptors; Introduction: Receptors; Definition of receptors; Identifying active centresEffect of denervation on receptors; Events at the cell membrane; Rate theory of drug action; Interaction at the Subcellular and Cellular Levels; Session 3: Subcellular Level; Introduction: Membranes; Subcellular particles; Phosphatidic acid cycle; Antihistamines and membrane permeability; Drug concentrations in vitro; Session 4: Cellular Level; Introduction: Cellular aspects; Reconstituting in vitro; In vitro and in vivo; Microsomal enzymes; Endoplasmic reticulum; Enzymes in young animals; Transaminase and GABA; Drug interactions; General considerations