|
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNISA996197616303316 |
|
|
Autore |
Shabarova Z (Zoe) |
|
|
Titolo |
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994] |
|
©1994 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-281-75881-7 |
9786611758813 |
3-527-61593-8 |
3-527-61592-X |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (606 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine |
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety |
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base |
|
|
|
|
|
|
|
|
|
|
|
Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References |
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions |
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides |
4.7 Hydrolysis of N-Glycosidic Bonds |
|
|
|
|
|
|
Sommario/riassunto |
|
Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations betwe |
|
|
|
|
|
|
|
| |