Contributi alla cronologia albanese : [Vol.] 1.: età romano-bizantina dalla morte di Costantino alla morte di Teodosio e alla definitiva divisione dell'impero 337-395 d. C. / a cura di Giuseppe Valentini

• Record Nr.: UNISA990002867930203316
• Pubbl/distr/stampa: Roma : Reale Accademia D'italia, 1942
• Descrizione fisica: 8. p. 356 con una carta geografica e due tavole ; 24 cm
• Collana: Fonti per la storia d'Albania ; 1
• Disciplina: 949.6503
• Soggetti: Storia - Albania
• Collocazione: 949.6503 CON
• Lingua di pubblicazione: Italiano
• Formato: Materiale a stampa
• Livello bibliografico: Monografia

A defence of the doctrine touching the spring and weight of the air [[electronic resource] /] / propos'd by Mr. R. Boyle in his new physico-mechanical experiments, against the objections of Franciscus Linus ; wherewith the objector's funicular hypothesis is also examin'd, by the author of those experiments

• Record Nr.: UNISA996385877003316
• Autore: Boyle Robert <1627-1691.>
• Pubbl/distr/stampa: London, : Printed by F.G. for Thomas Robinson ..., 1662
• Descrizione fisica: [12], 122 p., [1] leaf of plates : ill
• Altri autori (Persone): SharrockRobert <1630-1684.>
• Soggetti: Air; Air-pump; Physics - Experiments
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: This work contains the first formulation of Boyle's law.; Edited by Robert Sharrock.; Errata: p. 122.; Reproduction of original in British Library.
• Sommario/riassunto: eebo-0018

George Cosbuc : Studiu critic / Constanta Marinescu

• Record Nr.: UNIORUON00393774
• Autore: MARINESCU, Constanta
• Pubbl/distr/stampa: Bucuresti, : Editura Literara a Casei Scoalelor, 1923
• Descrizione fisica: 336 p. ; 20 cm.
• Disciplina: 859
• Soggetti: COSBUC GEORGE
• Lingua di pubblicazione: Rumeno
• Formato: Materiale a stampa
• Livello bibliografico: Monografia

Non-small Cell Lung Cancer: Current Therapies and New Targeted Treatments

• Record Nr.: UNINA9910557489703321
• Autore: Uchino Junji
• Pubbl/distr/stampa: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 online resource (258 p.)
• Soggetti: Medicine
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: Conventional lung cancer treatments were once limited to surgery, radiation, and chemotherapy. However, gefitinib, a targeted drug, was launched in 2004, and the situation changed. Cancer cases that were highly responsive to gefitinib were later discovered to have epithelial growth factor receptor (EGFR) mutations. This discovery opened the door for biomarker-based treatment strategies. Subsequently, several EGFR-tyrosine kinase inhibitors (TKI) were developed, and they became a new mainstay of treatment for non-small cell lung cancer. In recent years, many mechanisms of resistance to EGFR-TKI have been elucidated; a mutation in the T790M gene at exon 20 is found in half of the resistant cases. Hence, osimertinib, which specifically inhibits EGFR despite this T790M gene mutation, was developed to achieve long-term progression-free survival. Other driver mutations that are similar to the EGFR mutation were discovered, including the EML4-ALK fusion gene (discovered in 2007), ROS1 gene, and BRAF gene mutations. The TKIs for each of these fusion genes were developed and are used as therapeutic agents. Another advancement in advanced non-small cell lung cancer is the development of immune checkpoint inhibitors. Four PD-1/PD-L1 inhibitors, including nivolumab, are currently available for treatment of lung cancer. These drugs prevent an escape from the cancer immunity cycle. This ensures that cancer cells will express cancer antigens, causing an anticancer immune response. Due to ; cancer immunotherapy, long-term survival is possible. The biomarker development for cancer immunotherapy and its side effects are actively being studied.