Record Nr.

UNINA9910136278803321

Autore

Robert Marr

Titolo

Amyloid-beta clearance in Alzheimer's disease [[electronic resource] /] / topic editors: Robert A. Marr and Eliezer Masliah

Pubbl/distr/stampa


Frontiers Media SA, 2015
[Place of publication not identified] : , : Frontiers Media SA, , 2015
©2015

Descrizione fisica

1 online resource (111 pages) : illustrations; digital, PDF file(s)

Collana

Frontiers research topics

Frontiers in aging neuroscience

Disciplina

616.831

Soggetti

Alzheimer's disease

Alzheimer's disease - Pathogenesis

Alzheimer's disease - Molecular aspects

Neurosciences

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di bibliografia

Includes bibliographical references.

Sommario/riassunto

Strong evidence continues to accumulate indicating that amyloid-beta (Aβ) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aβ are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aβ clearance in AD. The topics covered include proteases that degrade Aβ and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

Record Nr.

UNIORUON00321362