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1. |
Record Nr. |
UNIBAS000036185 |
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Autore |
Bottini, Ottaviano <1905-> |
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Titolo |
Fertilizzazioni e fertilizzanti / Ottaviano Bottini |
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Pubbl/distr/stampa |
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Napoli : Publiscentia, [s.d.] |
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Descrizione fisica |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910140873003321 |
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Titolo |
Prodrugs and targeted delivery [[electronic resource] ] : towards better ADME properties / / edited by Jarkko Rautio |
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Pubbl/distr/stampa |
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Weinheim, Germany, : Wiley-VCH, 2011 |
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ISBN |
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1-283-14057-8 |
9786613140579 |
3-527-63318-9 |
3-527-63316-2 |
3-527-63317-0 |
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Descrizione fisica |
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1 online resource (522 p.) |
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Collana |
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Methods and principles in medicinal chemistry ; ; v. 47 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Prodrugs |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Prodrugs and Targeted Delivery: Towards Better ADME Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Prodrug Design and Intellectual Property; 1 Prodrug Strategies in Drug Design; 2 The Molecular Design of Prodrugs by Functional Group; 3 Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites; Part Two: Prodrugs Addressing ADMET Issues; 4 Increasing Lipophilicity for Oral Drug Delivery; 5 Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery |
6 Prodrugs Designed to Target Transporters for Oral Drug Delivery7 Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement; 8 Ocular Delivery Using Prodrugs; 9 Reducing Presystemic Drug Metabolism; 10 Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery; 11 Prodrug Approaches for Central Nervous System Delivery; 12 Directed Enzyme Prodrug Therapies; Part Three: Codrugs and Soft Drugs; 13 Improving the Use of Drug Combinations Through the Codrug Approach; 14 Soft Drugs; Part Four: Preclinical and Clinical Consideration for Prodrugs |
15 Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development16 The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs; Index |
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Sommario/riassunto |
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This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development. |
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3. |
Record Nr. |
UNINA9910797207203321 |
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Autore |
Dresbeck Rachel |
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Titolo |
Oregon disasters : true stories of tragedy and survival / / Rachel Dresbeck |
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Pubbl/distr/stampa |
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Guilford, Connecticut : , : Globe Pequot, , 2015 |
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©2015 |
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ISBN |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (230 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Natural disasters - Oregon |
Disasters - Oregon |
Oregon |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Acknowledgments; Introduction; CHAPTER 1 DEATH AND DESTRUCTION IN ITS WAKE The Heppner Flood (1903); CHAPTER 2 DEAD MAN'S HOTEL The Wreck of the Mimi (1913); CHAPTER 3 PORT TOWN IN FLAMES The Astoria Fire (1922); CHAPTER 4 DANGEROUS SLOPES The Mazamas on Coe Glacier (1927); CHAPTER 5 "JUST ONE MORE LOG" The Tillamook Burn (1933); CHAPTER 6 HERE TODAY, GONE TOMORROW The Vanport Flood (1948); CHAPTER 7 ARCTIC ILLUSIONS Three Blizzards (1950); CHAPTER 8 IT LOOKED LIKE THE END OF THE WORLD The Roseburg Blast (1959); CHAPTER 9 AN OCTOBER ODDITY The Columbus Day Storm (1962) |
CHAPTER 10 A COASTAL CATASTROPHE Tsunami (1964)CHAPTER 11 A WET CHRISTMAS The Willamette River Flood (1964); CHAPTER 12 MAYDAY IN AUGUST The Brookings-Harbor Rescues (1972); CHAPTER 13 "WE'RE GOING DOWN" The Last Journey of Flight 173 (1978); CHAPTER 14 "THIS IS IT!" The Eruption of Mount St. Helens (1980); CHAPTER 15 TRAGEDY ON MOUNT HOOD The Oregon Episcopal School Climb (1986); CHAPTER 16 BURNING FIELDS Chain-Reaction Car Accident (1988); CHAPTER 17 A WET AND WILD WINTER Raging Waters (1995-1996); CHAPTER 18 COOS BAY CATASTROPHE The Wreck of the New Carissa (1999) |
CHAPTER 19 BEWARE THE BERGSCHRUND Mount Hood Climbing |
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Accident (2002)CHAPTER 20 WHEN LIGHTNING STRIKES The Biscuit Fire (2002); CHAPTER 21 FATAL ERROR The Sinking of the Taki-Tooo (2003); Bibliography; About the Author |
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Sommario/riassunto |
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True accounts of major disasters in Oregon history are retold in this engagingly written collection. Among the true accounts dramatically retold are the deadly Mount Hood avalanche of 1927, the 1933 Tillamook forest fire (one of the worst in U.S. history), the devastating tsunami of 1964, and the 1903 flash flood in Heppner, which carried away a fourth of the town's inhabitants. Each story reveals not only the circumstances surrounding the disaster and the magnitude of the devastation but also the courage and ingenuity displayed by those who survived and the heroism of those who helped others, |
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4. |
Record Nr. |
UNIORUON00073225 |
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Autore |
HAWAD |
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Titolo |
Caravane de la soif : Poésies et calligraphies tifinagh originales de Hawad / Hawad ; Traduction du touareg (tamajaq) et adaptation française: Hawad et Hélène Claudot |
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Pubbl/distr/stampa |
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Aix-en-Provence, : Edisud, c1985 |
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ISBN |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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