Bridge across the Mississippi River at Bettendorf, Iowa. July 3 (legislative day, June 27), 1952. -- Ordered to be printed

• Record Nr.: UNINA9911079083503321
• Pubbl/distr/stampa: [Washington, D.C.] : , : [U.S. Government Printing Office], , 1952
• Descrizione fisica: 1 online resource (5 pages)
• Collana: Senate report / 82nd Congress, 2nd session. Senate ; ; no. 2087; [United States congressional serial set] ; ; [serial no. 11569]
• Altri autori (Persone): ChavezDennis <1888-1962> (Democrat (NM))
• Soggetti: Bridge construction industry; Bridges - Design and construction; Bridges; Legislative amendments; Toll bridges; Legislative materials.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Batch processed record: Metadata reviewed, not verified. Some fields updated by batch processes.; FDLP item number not assigned.

Adoption issues / / edited by Justin Healey

• Record Nr.: UNINA9911092357303321
• Pubbl/distr/stampa: Thirroul, N.S.W., : Spinney Press, 2011
• ISBN: 9781921507458; 1921507454
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (60 pages) : colour illustrations
• Collana: Issues in society ; ; v. 326
• Altri autori (Persone): HealeyJustin
• Disciplina: 362.7340994
• Soggetti: Adoption - Australia
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Chapter 1. Adoption trends in Australia -- Chapter 2. Search and reunion -- Chapter 3. Intercountry adoption.
• Sommario/riassunto: There has been an overall decline in the number of adoptions of Australian children over the last 25 years, however past and present adoption practices continue to raise a number of challenging and complex emotional and practical issues. This book examines the adoption experience in Australia, including local and intercountry adoption and the legal processes involved; adoption trends; identity and disclosure issues; the impacts of past coercive adoption practices on unmarried birth mothers and their children; post-adoption grief and loss; and the same-sex adoption law debate. A number of perso

The textbook as discourse : sociocultural dimensions of American schoolbooks / / edited by Eugene F. Provenzo, Jr., Annis N. Shaver, Manuel Bello

• Record Nr.: UNINA9911107938203321
• Pubbl/distr/stampa: New York : , : Routledge, , 2011
• ISBN: 1-136-86063-0; 1-136-86064-9; 1-283-04248-7; 9786613042484; 0-203-83602-2; 9780203836026
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (356 p.)
• Altri autori (Persone): BelloManuel; ProvenzoEugene F; ShaverAnnis N
• Disciplina: 371.3/20973; 371.320973
• Soggetti: Textbooks - United States; Textbooks - Social aspects - United States; United States; USA
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Book Cover; Title; Copyright; Contents; Preface; Acknowledgments; Chapter 1 Introduction; Part 1 Studies of American Textbooks and Their Content from the Late Eighteenth, Nineteenth, and Early Twentieth Centuries; Chapter 2 Education and the Iconography of the Republic: Patriotic Symbolism in the Frontispieces of Eighteenth- and Nineteenth- Century American Textbooks; Chapter 3 Values Expressed in American Children's Readers: 1800-1950; Chapter 4 Images of Women in Textbooks 1880-1920; Chapter 5 Catholic Textbooks and Cultural Legitimacy, 1840-1935; Chapter 6 The Discourse of Americanization Textbooks: 1914-; 1924Chapter 7 Textbooks and Reconstruction; Chapter 8 The Lingering Impact of the Scopes Trial on High School Biology Textbooks; Part 2 Ideology, Race, Ethnicity, Socio- Economic Status, Gender, Disability, and Religion in Twentieth- Century American Textbooks; Chapter 9 Ideology and United States History Textbooks; Chapter 10 The Representation of Christopher Columbus in High School History Textbooks: A Content Analysis; Chapter 11 Don Juan and Rebels under Palm Trees: Depictions of Latin Americans in US History Textbooks; Chapter 12 Race, Class, Gender, and Disability in Current TextbooksChapter 13 Brown-ing the American Textbook: History, Psychology, and the Origins of Modern Multiculturalism; Chapter 14 Making Dick and Jane: Historical Genesis of the Modern Basal Reader; Chapter 15 Harold Rugg vs. Horatio Alger: Social Class and Economic Opportunity, 1930-1960; Chapter 16 Textbook Content and Religious Fundamentalism; Bibliography; Index
• Sommario/riassunto: "The central assumption of The Textbook as Discourse is this: Interpreted in the flow of history, textbooks can provide important insights into the nature and meaning of a culture and the social and political discourses in which it is engaged. This book is about the social, political and cultural content of elementary and secondary textbooks in American education. It focuses on the nature of the discourses--the content and context--that represent what is included in textbooks. The term "discourse" provides the conceptual framework for the book, drawing on the work of the French social theorist Michel Foucault. The volume includes classic articles and book chapters as well as three original chapters written by the editors. To enhance its usefulness as a course text, each chapter includes an Overview, Key Concepts, and Questions for Reflection"--

1500 California place names : their origin and meaning / / William Bright

• Record Nr.: UNINA9911104012903321
• Autore: Bright William <1928-2006.>
• Pubbl/distr/stampa: Berkeley, : University of California Press, c1998
• ISBN: 9786613520289; 9781280085772; 1280085770; 9780520920545; 0520920546
• Descrizione fisica: 1 online resource (175 p.)
• Altri autori (Persone): GuddeErwin Gustav <1889-1969.>
• Disciplina: 917.94/001/4
• Soggetti: Names, Geographical - California; California History, Local
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "A revised version of 1000 California place names, by Erwin G. Gudde, third edition."
• Nota di contenuto: Front matter -- Preface -- Key to Pronunciation -- 1500 California Place Names
• Sommario/riassunto: This is the new "pocket" version of the classic California Place Names, first published by California in 1949. Erwin G. Gudde's monumental work, which went through several editions during its author's lifetime, has now been released in an expanded and updated edition by William Bright. The abridged version, originally called 1000 California Place Names, has grown to a dynamic 1500 California Place Names in Bright's hands. Those who have used and enjoyed 1000 California Place Names through the decades will be glad to know that 1500 California Place Names is not only bigger but better. This handbook focuses on two sorts of names: those that are well-known as destinations or geographical features of the state, such as La Jolla, Tahoe, and Alcatraz, and those that demand attention because of their problematic origins, whether Spanish like Bodega and Chamisal or Native American like Aguanga and Siskiyou.Names of the major Indian tribes of California are included, since some of them have been directly adapted ; as place names and others have been the source of a variety of names. Bright incorporates his own recent research and that of other linguists and local historians, giving us a much deeper appreciation of the tangled ancestry many California names embody. Featuring phonetic pronunciations for all the Golden State's tongue-twisting names, this is in effect a brand new book, indispensable to California residents and visitors alike.

Protein-protein complexes : analysis, modeling and drug design / / edited by Martin Zacharias

• Record Nr.: UNINA9911150427403321
• Pubbl/distr/stampa: London, : Imperial College Press, 2010
• ISBN: 9786612759840; 9781282759848; 1282759841; 9781848163409; 1848163401
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (400 p.)
• Altri autori (Persone): ZachariasMartin
• Disciplina: 572.6; 572.64
• Soggetti: Protein-protein interactions; Protein-protein interactions - Computer simulation; Protein-protein interactions - Mathematical models; Proteins - Structure; Drugs - Design
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- CONTENTS -- Preface -- 1. X-ray Study of Protein-Protein Complexes and Analysis of Interfaces Joel Janin -- 1.1 Introduction -- 1.2 Preparing Proteins for Structural Studies -- 1.3 Preparing Protein-Protein Complexes and Multi-component Assemblies -- 1.4 Crystallization and X-ray Studies -- 1.5 The Geometric Analysis of ; Protein-Protein Interfaces -- 1.6 Types and Sizes of Protein-Protein Interfaces -- 1.7 Chemical and Physical Chemical Properties of the Interfaces -- 1.8 Atomic Packing and Interface Topology -- 1.9 Conclusions and Outlook -- Acknowledgements -- References -- 2. A Structural Perspective on Protein-Protein Interactions in Macromolecular Assemblies Ranjit P. Bahadur -- 2.1 Introduction -- 2.2 The Icosahedral Viruses -- 2.3 The Structure of the Icosahedral Virus Capsids -- 2.4 Structural and Chemical Features of the Protein-Protein Interfaces -- 2.4.1 Symmetry and Size of Interfaces -- 2.4.2 Chemical Composition and Hydrogen Bonds -- 2.4.3 Atomic Packing of the Interfaces -- 2.4.4 Interface Patches and Segments -- 2.4.5 Residue Conservation -- 2.5 Comparison with Binary Interfaces -- 2.6 Mechanism of the Capsid Assembly -- 2.7 Conclusions and Outlook -- Acknowledgements -- References -- 3. Energetics of Protein-Protein Interactions Ilian Jelesarov -- 3.1 Introduction -- 3.2 Thermodynamic Formalism Describing the Energetics of Binding Reactions -- 3.2.1 Determination of the Binding Affinity -- 3.2.1.1 Heterologous Binding -- 3.2.1.2 Homologous Binding (Self-association) -- 3.2.2 Free Energy, Enthalpy and Entropy of Association -- 3.2.3 Determination of Energetic Changes -- 3.3 Experimental Methods to Measure the Energetics of Protein- Protein Association -- 3.3.1 Methods utilising Physical Separation of Species -- 3.3.2 Indirect Spectroscopic Methods -- 3.3.3 Methods Based on Refractive Phenomena -- 3.3.4 Kinetic Approaches.; 3.3.5 Isothermal Titration Calorimetry (ITC) -- 3.4 Energetics of Protein-Protein Interactions -- 3.4.1 Calculation of Binding Affinities -- 3.4.2 Structure-based Prediction of Binding Parameters -- 3.4.3 Understanding Binding: Are there Structure-Energy Relationships? -- 3.5 Conclusions and Outlook -- Acknowledgements -- References -- 4. Kinetics of Biomacromolecular Complex Formation: Theory and Experiment Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade -- 4.1 Introduction -- 4.1.1 Bimolecular Association -- 4.1.1.1 Diffusional Encounter Complex -- 4.1.1.2 Bound Complex -- 4.1.2 Molecular Transport -- 4.1.2.1 Diffusion -- 4.1.2.2 Viscosity -- 4.1.3 Molecular Interactions -- 4.1.3.1 Electrostatics -- 4.1.3.2 Hydrodynamics -- 4.1.3.3 Hydrophobicity -- 4.1.4 Reaction Rates -- 4.2 Experimental Techniques -- 4.2.1 Crystallography -- 4.2.2 Nuclear Magnetic Resonance (NMR) -- 4.2.3 Stopped-flow Methods (SF) -- 4.2.4 Fluorescence Recovery After Photobleaching (FRAP) -- 4.2.5 Fluorescence Resonance Energy Transfer (FRET) -- 4.2.6 Fluorescence Correlation Spectroscopy (FCS) -- 4.2.7 Force Probe Methods -- 4.2.8 Electrophoresis -- 4.2.9 Surface Plasmon Resonance (SPR) Biosensor -- 4.3 Theoretical and Computational Approaches -- 4.3.1 Computation of Bimolecular Rate Constants -- 4.3.2 Estimation of Rate Enhancements due to Electrostatic Interactions -- 4.4 Recent Advances in Computational Approaches -- 4.4.1 Protein-Protein Interactions -- 4.4.1.1 Computation of Rates -- 4.4.1.2 Determinants of Binding -- 4.4.1.3 Encounter Complex Quantification -- 4.4.1.4 Induced Fit Phenomena -- 4.4.1.5 Crowding Phenomena -- 4.4.2 Protein-nucleic Acid Interactions -- 4.4.2.1 Computation of Rates -- 4.4.2.2 Specificity and Nonspecificity -- 4.4.2.3 Chromatin Models -- 4.5 Conclusions and Outlook -- Acknowledgements -- References.; 5. Evolutionary Trace of Protein Functional Determinants Olivier Lichtarge -- 5.1 Introduction -- 5.2 Evolutionary Trace Basics: Which Amino Acids are Important in a Protein? -- 5.3 Validation Through Prospective Case Studies -- 5.3.1 Separation of Function -- 5.3.2 Rewiring Functions -- 5.3.3 Redirecting Protein Binding Specificity to DNA -- 5.3.4 Other Case Studies -- 5.4 Proteomics Properties of ; Evolutionary Important Residues -- 5.5 Molecular Determinants of GPCR Signal Transduction -- 5.6 Protein Function Prediction -- References -- 6. Protein-Protein Docking Adrien Saladin and Chantal Prevost -- 6.1 Introduction -- 6.2 Definition and Goals of Macromolecular Docking -- 6.2.1 Protein-Protein Docking Terminology -- 6.2.2 Goals and Strategies -- 6.3 Protein-Protein Docking Methods -- 6.3.1 Systematic Search Methods -- 6.3.1.1 Discrete Sampling: The Correlation Methods -- 6.3.1.2 Geometric Surface Matching -- 6.3.2 Guided Search Methods -- 6.3.2.1 Example of a Guided Search Programme: ICM-DISCO -- 6.3.2.2 Speeding up the Calculation -- 6.3.2.3 Data-driven Methods -- 6.3.3 Refinement -- 6.3.3.1 Increasing the Resolution -- 6.3.3.2 Accounting for Side Chain Conformational Change -- 6.3.3.3 Explicit Solvation -- 6.3.3.4 Hierarchical Approaches -- 6.3.4 Scoring the Predictions -- 6.4 Evaluation of the Docking Methods -- 6.4.1 The CAPRI Experience -- 6.4.2 Docking Benchmarks -- 6.4.3 Challenges -- 6.5 Conclusions and Outlook -- Acknowledgements -- References -- 7. Data-driven Docking: Using External Information to Spark the Biomolecular Rendez-vous Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin -- 7.1 Introduction -- 7.2 Stoichiometry and Composition -- 7.3 Shape of a Biomolecular Complex -- 7.4 Nature of the Interface: Which Residues are Engaged in a Date? -- 7.5 Orientation and Symmetry Problems.; 7.6 Flexibility: How to Cope with Conformational Changes Occurring upon Complex Formation? -- 7.7 How to Implement Data-driven Docking, the HADDOCK Example -- 7.8 Conclusions and Outlook -- Acknowledgements -- References -- 8. High-resolution Protein-Protein Docking Nir London and Ora Schueler-Furman -- 8.1 Introduction -- 8.1.1 From Molecules to Networks: Making Sense of Large-scale Data, Starting from the Atomic Details of Protein-Protein Interactions -- 8.1.2 Docking - The Creation of Protein Complex Structures Starting from the Monomers -- 8.1.3 Explicit Modelling of the Atomic Details of the Protein-Protein Interface Allows Distinguishing the Correct from Alternative Conformations -- 8.1.4 The Scope of this Chapter -- 8.2 High-resolution Docking, as Defined by CAPRI -- 8.3 Accounting for Conformational Changes of Monomers is Crucial to High-resolution Modelling -- 8.3.1 Modelling Side Chain Flexibility -- 8.3.2 Taking it to the Next Step: Modelling Backbone Flexibility -- 8.3.2.1 Ensemble Docking -- 8.3.2.2 Refinement and Minimization -- 8.3.2.3 Modelling Hinge Motion -- 8.4 The High-resolution RosettaDock Protocol - Explicit Modelling of Full Side Chain Flexibility (and Beyond) Allows Accurate Modelling of Protein Complexes -- 8.4.1 Adding Backbone Conformational Flexibility to the RosettaDock Protocol -- 8.4.2 Ensemble Docking with RosettaDock -- 8.5 Additional High-resolution Docking Approaches -- 8.5.1 High-accuracy Modelling with Rigid Body Docking -- 8.5.2 A New Generation of Docking Protocols: Combining Successful Approaches of Low-resolution and High-resolution Searches -- 8.6 The Contribution of High-resolution Docking to the Understanding of Interactions of Biological Interest -- 8.6.1 Entry Mechanism of Anthrax Toxin -- 8.6.2 Antitumor Monoclonal Antibody 806 (mAb806) and the Epidermal Growth Factor Receptor (EGFR).; 8.6.3 High-resolution Docking in the Service of Biochemistry -- 8.6.4 Applications of High-resolution Docking: Structure-based Prediction of Binding Specificity -- 8.7 Conclusions and Outlook -- 8.7.1 Impact of Docking on the Modelling Field -- Acknowledgements -- References -- 9. Scoring and Refinement of Predicted Protein-Protein Complexes Martin Zacharias -- 9.1 Introduction -- 9.2 Generation of Protein-Protein Complexes by Docking Methods -- 9.3 Protein-Protein ; Complexes Based on Homology to Known Complexes -- 9.4 Structural Refinement of Modelled Protein-Protein Complexes -- 9.4.1 Force Field Description of Proteins and Protein Complexes -- 9.4.2 Optimization Based on Energy Minimization -- 9.4.3 Accounting for Global Conformational Changes -- 9.4.4 Molecular Dynamics Simulation of Protein-Protein Complexes -- 9.4.5 Refinement of Docked Complexes by Molecular Dynamics Simulation -- 9.4.6 Monte Carlo and Brownian Dynamics Refinement of Docked Complexes -- 9.5 Scoring of Modelled Protein-Protein Complexes -- 9.5.1 Driving Forces for Molecular Association and the Scoring Problem -- 9.5.2 Scoring Based on Physical Force Fields -- 9.5.2.1 Scoring Based on Ensembles of Structures -- 9.5.3 Knowledge-based Scoring of Docked Complexes -- 9.5.3.1 Principles of Statistical Potentials to Score Predicted Complexes -- 9.5.3.2 Application of Statistical Potentials to Score Predicted Complexes -- 9.6 Conclusions and Outlook -- Acknowledgements -- References -- 10. Motif-mediated Protein Interactions and their Role in Disease Holger Dinkel and Heinrich Sticht -- 10.1 Introduction -- 10.2 Protein Interaction Domains -- 10.2.1 SH3 Domains -- 10.2.2 SH2 Domains -- 10.2.3 Signalling Adaptors: Proteins Containing Multiple Interaction Domains -- 10.3 Properties and Regulation of Motif-mediated Interactions -- 10.3.1 Inducible Interactions -- 10.3.2 Cooperative Effects.; 10.3.3 Mutually Exclusive Interactions.
• Sommario/riassunto: Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.