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1. |
Record Nr. |
UNINA9911148947703321 |
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Autore |
Greene Jack P |
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Titolo |
Pursuits of happiness : the social development of early modern British colonies and the formation of American culture / / Jack P. Greene |
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Pubbl/distr/stampa |
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Chapel Hill, : University of North Carolina Press, c1988 |
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ISBN |
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9798890865168 |
9780807864142 |
0807864145 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (xv, 284 pages) |
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Disciplina |
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Soggetti |
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Social change - United States |
Great Britain Colonies America History |
United States Civilization To 1783 |
United States Social conditions To 1865 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Preface; Prologue; 1. Two Models of English Colonization, 1600-1660; 2. Reconsiderations; 3. A Declension Model: New England, 1660-1760; 4. A Developmental Model: The Chesapeake, 1660-1760; 5. Exemplar and Variation: Britain and Ireland, 1660-1760; 6. Variations: The Middle Colonies and The Lower South, 1710-1760; 7. Variations: The Atlantic and Caribbean Islands, 1660-1760; 8. Convergence: Development of an American Society, 1720-1780; Epilogue; Notes; Index |
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Sommario/riassunto |
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In this book, Jack Greene reinterprets the meaning of American social development. Synthesizing literature of the previous two decades on the process of social development and the formation of American culture, he challenges the central assumptions that have traditionally been used to analyze colonial British American history.Greene argues that the New England declension model traditionally employed by historians is inappropriate for describing social change in all the other early modern British colonies. The settler societies established in Ireland, the Atlantic island colonies of Bermuda and |
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2. |
Record Nr. |
UNINA9911144295203321 |
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Autore |
Kerns Edward Harvel |
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Titolo |
Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization / / Edward H. Kerns and Li Di |
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Pubbl/distr/stampa |
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Amsterdam ; ; Boston, : Academic Press, c2008 |
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ISBN |
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1-281-76371-3 |
9786611763718 |
0-08-095162-7 |
0-08-055761-9 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (xix, 526 pages, 2 unnumbered pages of plates) : illustrations (some color) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Pharmaceutical chemistry |
Drugs - Structure-activity relationships |
Drug development |
Drugs - Design |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references (p. 492) and index. |
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Nota di contenuto |
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Front Cover; Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization; Copyright Page; Table of Contents; Preface; Dedication; Part 1 Introductory Concepts; Chapter 1 Introduction; Problems; References; Chapter 2 Advantages of Good Drug-like Properties; 2.1 Drug-like Properties Are an Integral Part of Drug Discovery; 2.1.1 Many Properties Are of Interest in Discovery; 2.1.2 Introduction to the Drug Discovery and Development Process; 2.1.3 Development Attrition is Reduced by Improving Drug Properties |
2.1.4 Poor Drug Properties Also Cause Discovery Inefficiencies; 2.1.5 Marginal Drug Properties Cause Inefficiencies During Development; 2.1.6 Poor Properties Can Cause Poor Discovery Research; 2.2 Changing Emphasis on Properties in Discovery; 2.3 Property Profiling in Discovery; 2.4 Drug-like Property Optimization in Discovery; Problems; References; Chapter 3 Barriers to Drug Exposure in Living Systems; 3.1 Introduction to Barriers; 3.2 Drug Dosing; 3.3 Barriers in the Mouth and Stomach; 3.4 Gastrointestinal Tract Barriers; 3.4.1 Permeation of the |
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Gastrointestinal Cellular Membrane |
3.4.2 Passive Diffusion at the Molecular Level; 3.4.3 Metabolism in the Intestine; 3.4.4 Enzymatic Hydrolysis in the Intestine; 3.4.5 Absorption Enhancement in the Intestine; 3.5 Barriers in the Bloodstream; 3.5.1 Plasma Enzyme Hydrolysis; 3.5.2 Plasma Protein Binding; 3.5.3 Red Blood Cell Binding; 3.6 Barriers in the Liver; 3.6.1 Metabolism; 3.6.2 Biliary Excretion; 3.7 Barriers in the Kidney; 3.8 Blood-Tissue Barriers; 3.9 Tissue Distribution; 3.10 Consequences of Chirality on Barriers and Properties; 3.11 Overview of In Vivo Barriers; Problems; References; Part 2 Physicochemical Properties |
Chapter 4 Rules for Rapid Property Profiling from Structure; 4.1 Lipinski Rules; 4.2 Veber Rules; 4.3 Other Rules; 4.4 Application of Rules for Compound Assessment; Problems; References; Chapter 5 Lipophilicity; 5.1 Lipophilicity Fundamentals; 5.2 Lipophilicity Effects; 5.3 Lipophilicity Case Studies and Structure Modification; Problems; References; Chapter 6 pKa; 6.1 pKa Fundamentals; 6.2 pKa Effects; 6.3 pKa Case Studies; 6.4 Structure Modification Strategies for pKa; Problems; References; Chapter 7 Solubility; 7.1 Solubility Fundamentals |
7.1.1 Solubility Varies with Structure and Physical Conditions; 7.1.2 Dissolution Rate; 7.1.3 Structural Properties Affect Solubility; 7.1.4 Kinetic and Thermodynamic Solubility; 7.2 Effects of Solubility; 7.2.1 Low Solubility Limits Absorption and Causes Low Oral Bioavailability; 7.2.2 Good Solubility is Essential for IV Formulation; 7.2.3 Acceptance Criteria and Classifications for Solubility; 7.2.4 Molecular Properties for Solubility and Permeability Often are Opposed; 7.3 Effects of Physiology on Solubility and Absorption; 7.3.1 Physiology of the Gastrointestinal Tract; 7.3.2 Species Differences in Gastrointestinal Tract |
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Sommario/riassunto |
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. |
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