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1. |
Record Nr. |
UNINA9911115442703321 |
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Autore |
Christian Diener |
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Titolo |
Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (142 p.) |
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Collana |
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Frontiers Research Topics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options.Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current "omics" technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell's metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, |
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mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research. |
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2. |
Record Nr. |
UNINA9911132336503321 |
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Autore |
Serna Saldívar Sergio R. Othón |
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Titolo |
Cereal grains : properties, processing, and nutritional attributes / / Sergio O. Serna-Saldivar |
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Pubbl/distr/stampa |
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Boca Raton, FL : , : CRC Press, , [2016] |
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©2010 |
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ISBN |
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1-4398-9947-9 |
0-429-11211-4 |
1-4398-8209-6 |
9780429112119 |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (796 p.) |
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Collana |
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Food Preservation Technology Series |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Front Cover; FOOD PRESERVATION TECHNOLOGY SERIES; Dedication; Contents; Foreword; Preface; Acknowledgments; The Author; List of Tables; List of Figures; Chapter 1: Cereal Grains; Body; Chapter 2: Physical Properties, Grading, and Specialty Grains; Chapter 3: Chemical Composition of Cereal Grains; Chapter 4: Grain Development, Morphology, and Structure; Chapter 5: Storage of Cereal Grains; Chapter 6: Grain Storage Pests; Chapter 7: Dry-Milling Operations; Chapter 8: Wet-Milling Operations; Chapter 9: Milling of Maize into Lime-Cooked Products; Chapter 10: Manufacturing of Bakery Products |
Chapter 11: Manufacturing of Breakfast Cereals Chapter 12: Manufacturing of Cereal-Based Snacks; Chapter 13: Industrial |
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Production of Modified Starches and Syrups; Chapter 14: Production of Malts, Beers, Alcohol Spirits, and Fuel Ethanol; Chapter 15: Quality Control of Cereal Grains and Their Products; Chapter 16: Production of Cereal-Based Traditional Foods; Chapter 17: Role of Cereals in Human Nutrition and Health; Chapter 18: Cereals as Feed stuffs for Animal Nutrition; Glossary; Index; Back Cover |
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Sommario/riassunto |
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While cereals remain the world’s largest food yield – with more than 2.3 billion metric tons produced annually – consumer demands are on the rise for healthier cereal products with greater nutrition. Cereal Grains: Properties, Processing, and Nutritional Attributes provides a complete exploration of the scientific principles related to domestication, morphology, production, and storage of cereal grains. It also describes their physical and chemical characteristics and explains how these properties relate to industrial processing and nutritional value. |
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3. |
Record Nr. |
UNINA9911133248903321 |
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Autore |
Marchand Peter J |
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Titolo |
Life in the Cold : An Introduction to Winter Ecology, fourth edition / / Peter J. Marchand |
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Pubbl/distr/stampa |
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Lebanon, NH : , : University Press of New England, , [2014] |
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ISBN |
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Edizione |
[Fourth edition.] |
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Descrizione fisica |
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1 online resource (321 p.) |
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Disciplina |
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Soggetti |
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Ecology |
Winter |
Cold adaptation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Title Page; Table of Contents; Preface to the Fourth Edition; 1 | Winter Paths: Options for Overwintering Success; Migration; Hibernation; Resistance; 2 | The Changing Snowpack; Destructive Metamorphism; Constructive Metamorphism; Melt Metamorphism; The Insulative Value |
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of a Snowcover; Snow and Radiant Energy; 3 | Plants and the Winter Environment; Acclimating to the Cold; Weathering the Winter Drought; The Evergreen Advantage; Mechanical Forces of Winter; 4 | Animals and the Winter Environment; The Basics of Energy Exchange; Warm Bodies in Cold Environments; Bergmann's and Gloger's Rules |
The Cold-Blooded Gamble5 | Life under Ice; Temperature/Density Relationships; Freezing around the Edges; Dormancy versus Activity; Dealing with Oxygen Depletion; 6 | Plant-Animal Interactions: Food for Thought; Bargaining with Hoarders; Coping with Browsers; Plants and the Quality of Subnivean Life; The Carbon Dioxide Debate; 7 | Winter Profiles: A Season in the Lives of Selected Animals; The Northern Cervids; Semiaquatic Mammals; Gallinaceous Birds; 8 | Humans in Cold Places; Circulatory Responses to Cold; Increasing Heat Output; Mind over Temperature; 9 | The Changing Snowpack, II |
Broken MirrorSpecies on the Move; Unwelcome Thaw; Glossary; Notes; Index; List of Unit Conversion Factors |
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Sommario/riassunto |
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A revised edition of a classic work on cold climate ecosystems, with a new chapter on climate change |
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