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1. |
Record Nr. |
UNINA9911109346803321 |
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Autore |
Hughes Amy |
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Titolo |
Spectacles of reform : theater and activism in nineteenth-century America / / Amy E. Hughes |
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Pubbl/distr/stampa |
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Ann Arbor : , : University of Michigan Press, , c2012 |
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ISBN |
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9781283941600 |
1283941600 |
9780472028894 |
0472028898 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (261 p.) |
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Disciplina |
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Soggetti |
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Theater - United States - History - 19th century |
Theater and society - United States - History - 19th century |
American drama - 19th century - History and criticism |
Spectacular, The, in literature |
Spectacular, The - History - 19th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 213-234) and index. |
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Nota di contenuto |
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The body as/in/at the spectacle -- The delirium tremens: spectacular insanity in The drunkard -- The fugitive slave: Eliza's flight in Uncle Tom's cabin -- The railroad rescue: suffrage and citizenship in Under the gaslight -- Afterword: our sensations, our heroes, our freaks. |
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Sommario/riassunto |
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Reveals the crucial role that spectacle played in American activism and reform movements in the 1800s. |
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2. |
Record Nr. |
UNINA9911131349103321 |
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Autore |
Whitfield James F |
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Titolo |
Calcium : the grand-master cell signaler / / James F. Whitfield and Balu Chakravarthy |
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Pubbl/distr/stampa |
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Ottawa, : NRC Research Press, 2001 |
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ISBN |
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9786610452040 |
1-280-45204-8 |
1-4593-0348-2 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (vii, 247 pages) : illustrations (some color) |
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Altri autori (Persone) |
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ChakravarthyBalu R. <1956-> |
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Disciplina |
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Soggetti |
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Calcium - Physiological effect |
Cellular signal transduction |
Cell differentiation |
Cell cycle |
Cell proliferation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Includes abstract in French. |
"NRC no. 42360"--T.p. verso. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover page Publishing information Title page Copyright Contents Abstract/résumé Introduction 1. Cell cycles and checkpoints 2. Calcium - a cell cycle driver 3. Calcium and keratinocyte diffpoptosis 4. Calcium and colon cell ciffpoptosis 5. Calcium and neurons 6. But what about Ca²+ and plants? 7. Summary Index |
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Sommario/riassunto |
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This unique book has an exciting story to tell about Ca2+, the versatile Master Cell Signaler whose influence reaches into all corners of the cell and controls cell proliferation, differentiation, cell functions too numerous to list here, and even cell death. |
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3. |
Record Nr. |
UNINA9911150316703321 |
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Titolo |
Human oncogenic viruses / / editors, Jing-Hsiung James Ou, T. S. Benedict Yen |
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Pubbl/distr/stampa |
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New Jersey, : World Scientific, c2010 |
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ISBN |
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9786612760426 |
9781282760424 |
1282760424 |
9789812833471 |
9812833471 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (352 p.) |
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Altri autori (Persone) |
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OuJ.-H. James <1954-> (Jing-hsiung James) |
YenT. S. Benedict <1953-2009.> (Tien-Sze Benedict) |
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Disciplina |
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616.9101 |
616.99/4019 |
616.994019 |
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Soggetti |
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Oncogenic viruses |
Hepatitis viruses |
Herpesviruses |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Foreword; Preface; Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou; 1. Introduction and Historical Aspects; 2. Human Oncogenic Viruses; 2.1. Hepatitis B Virus (HBV); 2.2. Hepatitis C Virus (HCV); 2.3. Human Papilloma Virus (HPV); 2.4. Epstein-Barr Virus (EBV); 2.5. Kaposi's Sarcoma-associated Herpesvirus (KSHV); 2.6. Human T-cell Leukemia Virus-1 (HTLV-1); 3. Mechanisms of Virus-induced Cellular Transformation; 3.1. Perturbation of Signaling Pathways; 3.1.1. Mimicking the signaling ligands |
3.1.2. Mimicking the cellular signaling receptors3.1.3. Mimicking the intracellular signaling adaptors; 3.1.4. Activation of cell surface receptors; 3.2. Deregulation of the Cell Cycle; 3.2.1. Abrogation of the RB function; 3.2.2. Enhancement of CDK activities; 3.2.3. Targeting of cyclin; 3.3. Escape of Apoptosis; 3.3.1. Inactivation of the "gatekeeper" |
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p53; 3.3.2. Expression of viral version of Bcl-2 (vBcl-2); 3.4. Immortalization of Cells; 3.5. Induction of Genetic Instability; 3.6. Insertional Mutagenesis; 3.7. Induction of Chronic Inflammation; 4. Concluding Remarks; Bibliography |
Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T. S. Benedict Yen1. Hepatitis B Virus and Hepatocellular Carcinoma; 2. Biology and Epidemiology of HBV; 3. HBV Virology; 4. Prevention and Treatment of HBV; 5. Mechanisms of HBV Carcinogenesis; 5.1. Overview; 5.2. HBV-specific Factors; 5.2.1. X protein; 5.2.1.1. Function of X protein in the HBV life cycle; 5.2.1.2. Effect of X protein on transcription; 5.2.1.3. Effect of X protein on viral replication; 5.2.1.4. X protein and DDB1; 5.2.1.5. X-protein carcinogenesis; 5.2.2. Other viral proteins potentially involved in carcinogenesis |
5.2.2.1. Truncated MSP5.2.2.2. preS2 mutants; 5.2.2.3. Core gene mutants; 5.2.3. Insertional mutagenesis; 5.3. Role of Liver Injury and Inflammation; 5.4. Dietary Carcinogens; 5.5. Other Aspects of HBV Oncogenesis; 5.5.1. Role of genotypes; 5.5.2. Role of sex hormones; 6. Summary; Note; References; Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M. C. Lai; 1. Introduction; 2. Molecular Carcinogenesis of HCV; 2.1. Induction of Mutator Phenotype; 2.2. Chromosome Translocation; 2.3. Reactive Oxygen Species (ROS); 2.4. Nitric Oxide |
2.5. Inhibition of DNA Damage Repair2.6. Oncogenic Activities of the HCV Core Protein; 2.6.1. TNF-α; 2.6.2. MAPK and AP-1; 2.6.3. NF-κB; 2.6.4. Oxidative stress; 2.6.5. Insulin resistance; 2.6.6. PPARα; 2.6.7. Proteasome activator PA28γ; 2.6.8. SOCS-1; 2.6.9. p53; 2.7. Oncogenic Activities of the HCV NS5A Protein; 3. Other Causative Factors in HCV-associated HCC; 3.1. Chronic Liver Inflammation; 3.2. Alcohol; 4. Endoplasmic Reticulum Stress and HCV Pathogenesis; 5. Gene Expression Profile of HCC; 6. HCV and Lymphomagenesis; 6.1. Induction of IgHypermutation by HCV |
6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV |
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Sommario/riassunto |
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Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epstein-Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fe |
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