|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9911094303703321 |
|
|
Titolo |
DNA polymerases : discovery, characterization and functions in cellular DNA transactions / / Ulrich Hubscher ... [et al.] |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Singapore, : World Scientific, c2010 |
|
|
|
|
|
|
|
ISBN |
|
9786612763595 |
9781282763593 |
1282763598 |
9789814299176 |
9814299170 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (340 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
DNA polymerases |
Biochemistry |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references. |
|
|
|
|
|
|
Nota di contenuto |
|
Preface; Contents; 1. History and Discovery of DNA Polymerases; 2. DNA Polymerases in the Three Kingdoms of Life: Bacteria, Archaea and Eukaryotes; 3. Structural and Functional Aspects of the Prokaryotic and Archaea DNA Polymerase Families; 4. Structural and Functional Aspects of the Eukaryotic DNA Polymerase Families; 5. Global Functions of DNA Polymerases; 6. Viral DNA Polymerases; 7. Synthetic Evolution of DNA Polymerases with Novel Properties; 8. DNA Polymerases and Diseases; 9. DNA Polymerases and Chemotherapy |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex physiological processes of DNA replication and repair. Besides the tasks in vivo, DNA polymerases are the workhorses in numerous biotechniques such as polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics, as well as techniques to analyze ancient and otherwise damaged DNA. The authors have recently witnessed the discovery of a plethora of novel DNA polymerases with specialized properties whose physiological func |
|
|
|
|
|
|
|