1.

Record Nr.

UNINA9911020178503321

Titolo

Atherosclerosis : molecular and cellular mechanisms / / edited by Sarah Jane George and Jason Johnson

Pubbl/distr/stampa

Weinheim, : Wiley-VCH Verlag GmbH & Co., 2010

ISBN

9786612682810

9781282682818

1282682814

9783527629589

3527629580

9783527629596

3527629599

Descrizione fisica

1 online resource (422 p.)

Classificazione

Veh

Disciplina

616.136

Soggetti

Atherosclerosis

Arteries - Diseases

Aufsatzsammlung

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Atherosclerosis: Molecular and Cellular Mechanisms; Contents; Preface; List of Contributors; PART I: Introduction; 1: Pathogenesis of Atherosclerosis; PART II: PRO-Inflammatory Factors; 2: Chemokines and Atherosclerosis: A Critical Assessment of Therapeutic Targets; 3: Adhesion Molecules and Atherosclerosis; 4: Cytokines and Atherosclerosis; 5: Toll-Like Receptors in Atherosclerosis; 6: PPAR-Based Therapies for the Management of Atherosclerosis; 7: Pentraxins in Vascular Pathology: The Role of PTX3; PART III: Proteases; 8: Metalloproteinases, the Endothelium, and Atherosclerosis

9: Cathepsins in Atherosclerosis10: The Plasmin System and Atherosclerosis; 11: Mast Cell Proteases and Atherosclerosis; PART IV: Hyperlipidemia; 12: Macrophage Foam Cell Formation: The Pathways to Cholesterol Engorgement; PART V: Oxidative Stress; 13: NADPH Oxidase and Atherosclerosis; 14: Uncoupling of Endothelial Nitric Oxide Synthase in Atherosclerosis; 15: Heme Oxygenase-1 and



Atherosclerosis; PART VI: Cell Growth and Phenotype; 16: Phenotypic Heterogeneity of Smooth Muscle Cells-Implications for Atherosclerosis

17: Platelets: Their Role in Atherogenesis and Thrombosis in Coronary Artery Disease18: Modulators of Monocyte and Macrophage Phenotypes in Atherosclerosis; Index

Sommario/riassunto

With atherosclerosis being the number one cause of death in the western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque. Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner. A must-have for master and PhD students, researcher