| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNISALENTO991001962459707536 |
|
|
Titolo |
Biblia sacra : vulgatae editionis Sixti 5. Pontificis Maximi jussu recognita et Clementis 8. auctoritate edita |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Paris : Garnier, stampa 1922 |
|
|
|
|
|
|
|
Edizione |
[Nova editio accuratissime emendata a DD. Archiepiscopo parisiensi approvata] |
|
|
|
|
|
|
|
Descrizione fisica |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
2. |
Record Nr. |
UNISALENTO991003431109707536 |
|
|
Autore |
Seidel Menchi, Silvana |
|
|
Titolo |
Ketzerverfolgung : im 16. und frühen 17. Jahrhundert / in Gemeinschaft mit Hans Rudolf Guggisberg und Bernd Moeller herausgegeben von Silvana Seidel Menchi |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Wiesbaden : Harrassowitz, 1992 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
|
|
|
|
|
Collana |
|
Wolfenbütteler Forschungen ; Bd. 51 |
|
|
|
|
|
|
Altri autori (Persone) |
|
Guggisberg, Hans R.author |
Moeller, Bernd |
|
|
|
|
|
|
|
|
Soggetti |
|
Heresies, Christian - Storia - Congressi |
Heretics, Christian - Congressi |
Persecuzioni - Europa - Storia |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
"Vorträge gehalten anlässlich eines Arbeitsrgesprächs vom 1. bis 5. Oktober 1989 in der Herzog August Bibliothek Wolfenbüttel"--Verso of t.p. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3. |
Record Nr. |
UNINA9910163348503321 |
|
|
Autore |
Rainer Peter |
|
|
Titolo |
Pipeline to battle : an engineer's adventures with the British Eighth army / / Major Peter Rainer |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
[Place of publication not identified] : , : Pickle Partners Publishing, , 2013 |
|
©1943 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (319 pages) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
|
|
|
|
|
|
|
4. |
Record Nr. |
UNINA9911020074203321 |
|
|
Titolo |
Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, : Wiley-VCH, c2009 |
|
|
|
|
|
|
|
ISBN |
|
9786612307041 |
9781282307049 |
1282307045 |
9783527623860 |
3527623868 |
9783527623877 |
3527623876 |
|
|
|
|
|
|
|
|
Edizione |
[2nd, completely rev. ed /] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (653 p.) |
|
|
|
|
|
|
Collana |
|
Methods and principles in medicinal chemistry ; ; 40 |
|
|
|
|
|
|
Altri autori (Persone) |
|
WaterbeemdHan van de |
TestaBernard |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Drugs - Bioavailability |
Pharmaceutical chemistry |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability; Contents; List of Contributors; Preface; A Personal Foreword; 1 Introduction: The Why and How of Drug Bioavailability Research; 1.1 Dening Bioavailability; 1.1.1 The Biological Context; 1.1.2 A Pharmacokinetic Overview; 1.1.3 Specic Issues; 1.2 Presentation and Layout of the Book; References; Part One Physicochemical Aspects of Drug Dissolution and Solubility; 2 Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays; 2.1 Introduction; 2.1.1 Denition of Aqueous Solubility |
2.1.2 Aqueous Solubility in Different Phases of Drug Discovery2.2 Aqueous Solubility in Hit Identication; 2.2.1 Aqueous Solubility from DMSO Solutions; 2.2.1.1 Turbidimetric Methods; 2.2.1.2 UV Absorption Methods; 2.2.1.3 Alternative Detection Methodology; 2.2.1.4 Application of DMSO-Based Solubility Assays; 2.3 Aqueous Solubility in |
|
|
|
|
|
|
|
|
|
|
|
Lead Identication and Lead Optimization; 2.3.1 Dried-Down Solution Methods; 2.3.2 Solubility from Solid; 2.3.3 Thermodynamic Solubility Assays with Solid-State Characterization; 2.3.4 Solubility by Potentiometry |
2.3.5 Application of Thermodynamic Solubility Data in LI and LO2.4 Conclusions; References; 3 Gastrointestinal Dissolution and Absorption of Class II Drugs; 3.1 Introduction; 3.2 Drug Absorption and the BCS; 3.3 Class II Drugs; 3.4 GI Physiological Variables Affecting Class II Drug Dissolution; 3.4.1 Bile Salts; 3.4.2 GI pH; 3.4.3 GI Transit; 3.4.4 Drug Particle Size; 3.4.5 Volume Available for Dissolution; 3.5 In Vitro Dissolution Tests for Class II Drugs; 3.5.1 Biorelevant Media; 3.5.2 Dynamic Lipolysis Model; 3.6 BCS-Based FDA Guidelines: Implications for Class II Drugs |
3.6.1 Potential of Redening BCS Solubility Class Boundary3.6.2 Biowaiver Extension Potential for Class II Drugs; 3.7 Conclusions; References; 4 In Silico Prediction of Solubility; 4.1 Introduction; 4.2 What Solubility Measures to Model?; 4.3 Is the Data Set Suitable for Modeling?; 4.4 Descriptors and Modeling Methods for Developing Solubility Models; 4.5 Comparing Literature Solubility Models; 4.6 What Is the Inuence of the Domain of Applicability?; 4.7 Can We Tell when Good Predictions Are Made?; 4.8 Conclusions; References |
Part Two Physicochemical and Biological Studies of Membrane Permeability and Oral Absorption5 Physicochemical Approaches to Drug Absorption; 5.1 Introduction; 5.2 Physicochemical Properties and Pharmacokinetics; 5.2.1 DMPK; 5.2.2 Lipophilicity, Permeability, and Absorption; 5.2.3 Estimation of Volume of Distribution from Physical Chemistry; 5.2.4 Plasma Protein Binding and Physicochemical Properties; 5.3 Dissolution and Solubility; 5.3.1 Calculated Solubility; 5.4 Ionization (pKa); 5.4.1 Calculated pKa; 5.5 Molecular Size and Shape; 5.5.1 Calculated Size Descriptors; 5.6 Hydrogen Bonding |
5.6.1 Calculated Hydrogen-Bonding Descriptors |
|
|
|
|
|
|
Sommario/riassunto |
|
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ioniza |
|
|
|
|
|
|
|
| |