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Record Nr. |
UNINA9911019963403321 |
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Titolo |
Fragment-based drug discovery : a practical approach / / editors, Edward R. Zartler, Michael J. Shapiro |
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Pubbl/distr/stampa |
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Chichester, U.K., : John Wiley & Sons, 2008 |
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ISBN |
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9786612342752 |
9781282342750 |
1282342754 |
9780470721551 |
0470721553 |
9780470721568 |
0470721561 |
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Descrizione fisica |
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1 online resource (297 p.) |
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Altri autori (Persone) |
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ZartlerEdward |
ShapiroMichael (Michael J.) |
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Disciplina |
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Soggetti |
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Drug development |
Drugs - Design |
Ligands (Biochemistry) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation |
9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index |
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Sommario/riassunto |
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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical ti |
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