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Record Nr. |
UNINA9910784637903321 |
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Titolo |
Surgical research / / editors, Wiley W. Souba, Douglas W. Wilmore |
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Pubbl/distr/stampa |
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San Diego, CA : , : Academic Press, , 2001 |
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ISBN |
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1-281-79558-5 |
9786611795580 |
0-08-054214-X |
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Descrizione fisica |
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1 online resource (1489 pages) : illustrations |
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Altri autori (Persone) |
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SoubaWiley W |
WilmoreDouglas W <1938-> (Douglas Wayne) |
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Disciplina |
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Soggetti |
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Surgery - Research |
Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Surgical Research; Copyright Page; Contents; Contributors; Foreword; Preface; Chapter 1. Getting Started; Text; Chapter 2. Assessing Available Information; I. Introduction; II. Sources of Information; III. Assessing Published Studies: External Measures of Quality; IV. How to Read and Evaluate Published Studies; V. Suggestions for the Future; References; Chapter 3. Organizing and Preliminary Planning for Surgical Research; I. Research as the Foundation of an Academic Surgical Career; II. Research Training; III. Choosing a Research Mentor; IV. Choosing a Research Topic |
V. General Preparation VI. Experimental Preparation; VII. Grant Preparation; References; Chapter 4. Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents; I. Introduction; II. Research Utilizing Laboratory Animals; III. Human Subject Research; IV. Institutional Safety Committees; V. Summary; References; Chapter 5. Grantsmanship; I. Introduction; II. Common Myths, Misconceptions, and Mistruths; III. Grant Preparation-General Comments; IV. Grant Preparation-Specific Comments; V. Other Considerations; VI. Conclusions; References |
Chapter 6. Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States |
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Regulations I. History of Informed Consent; II. United States Regulations Governing Informed Consent; III. Conclusion; References; Chapter 7. Animal Care and Maintenance; I. Introduction; II. Ethical and Regulatory Overview; III. Available Resources; IV. Surgical Facility Design; V. Anesthesia; VI. Anesthetic Recommendations by Species; VII. Analgesia; VIII. Resources; References; Chapter 8. Funding Strategies and Agencies: Academic-Industrial Relationships |
Intellectual Property I. Introduction; II. Academic Agencies; III. Industry; IV. State Incubators and Local University Incubators; V. Intellectual Property; Chapter 9. Statistical Considerations; I. Introduction; II. Hypothesis Testing; III. Sample Size Calculations; IV. Summary; References; Chapter 10. Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment; I. Introduction; II. Dimensions of Risk; III. Data Sources; IV. Multivariate Modeling Framework; V. Incorporating Risk in Multivariate Models |
VI. Approaches for Improved Estimates of Treatment Effectiveness in Nonexperimental Studies: The Propensity Score and Instrumental Variables; VII. Conclusions; References; Chapter 11. Measuring Surgical Outcomes; I. Introduction; II. Generic Measures of Health Status; III. Specific Measures of Health Status; IV. Utilities; V. Patient Satisfaction; References; Appendix: The SF-36V2 Health Survey Questionnaire; Chapter 12. Design of Clinical Trials; I. Introduction; II. Hypotheses, Specific Aims, and Endpoints; III. Patient Eligibility; IV. Structure of Clinical Trials; V. Treatment Plan; I. Data Collection and Quality Assurance |
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Sommario/riassunto |
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With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators. Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. |
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2. |
Record Nr. |
UNINA9911019856003321 |
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Titolo |
Organosulfur chemistry in asymmetric synthesis / / edited by Takeshi Toru and Carsten Bolm |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, c2008 |
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ISBN |
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9786611947170 |
9781281947178 |
1281947172 |
9783527623235 |
352762323X |
9783527623242 |
3527623248 |
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Descrizione fisica |
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1 online resource (450 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Organosulfur compounds |
Asymmetric synthesis |
Enantioselective catalysis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Organosulfur Chemistry in Asymmetric Synthesis; Contents; Preface; List of Contributors; 1 Asymmetric Synthesis of Chiral Sulfoxides; 1.1 Chiral Sulfoxides; 1.1.1 Introduction; 1.1.2 The Main Routes to Chiral Sulfoxides; 1.2 Use of Chiral Sulfur Precursors; 1.2.1 Sulfinates (Andersen Method); 1.2.2 Diastereoselective Formation of Sulfinates; 1.2.3 Sulfinates from Sulfites; 1.2.4 Sulfinamides; 1.3 Catalytic Enantioselective Sulfide Oxidation; 1.3.1 Titanium Complexes; 1.3.1.1 Diesters of Tartaric Acid; 1.3.1.2 C(2)-Symmetric 1,2-Diols as Ligands; 1.3.1.3 Binaphthol and Derivatives |
1.3.1.4 C(3)-Symmetric Triethanolamine Ligands1.3.1.5 Ti (Salen) Catalysts; 1.3.2 Manganese Complexes; 1.3.3 Vanadium Complexes; 1.3.4 Molybdenum Complexes; 1.3.5 Iron Complexes; 1.3.6 Miscellaneous; 1.4 Catalytic Arylation of Sulfenate Anions; 1.5 Enantioselective Oxidation of Sulfides; 1.6 Summary; References; 2 |
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Asymmetric Synthesis of Optically Active Sulfinic Acid Esters; 2.1 Introduction; 2.2 Enantiomeric Sulfinic Acid Esters; 2.3 Diastereomeric Sulfinic Acid Esters; References; 3 Asymmetric Transformations Mediated by Sulfinyl Groups; 3.1 Introduction |
3.2 Nucleophilic Additions to C=O and C=N Bonds Mediated by α-Sulfinyl Groups3.2.1 β-Ketosulfoxides; 3.2.1.1 Reduction Reactions; 3.2.1.2 Alkylation Reactions; 3.2.1.3 Aldol Reaction with β-Ketosulfoxides Acting as Electrophiles; 3.2.1.4 Hydrocyanation Reactions; 3.2.2 β-Imino(enamino)sulfoxides; 3.3 Conjugate Additions to α,β-Unsaturated Sulfoxides; 3.3.1 Nucleophilic Additions; 3.3.1.1 (E) and (Z)-2-Substituted Vinyl Sulfoxides; 3.3.1.2 1-Substituted Vinyl Sulfoxides; 3.3.2 Tandem Reactions; 3.3.3 Radical Conjugate Additions and Other Reactions; 3.4 Cycloadditions |
3.4.1 Asymmetric Diels-Alder Reactions3.4.1.1 Sulfinyl Dienophiles; 3.4.1.2 Sulfinyl Dienes; 3.4.2 Asymmetric Hetero Diels-Alder Reactions; 3.4.3 Asymmetric 1,3-Dipolar Cycloadditions; 3.4.3.1 Reactions with Nitrones; 3.4.3.2 Reactions with Azomethine Ylides; 3.4.3.3 Reactions with Nitrile Oxides; 3.4.3.4 Reactions with Diazoalkanes; 3.4.3.5 Reactions with Other Dipoles; 3.4.4 Other Asymmetric Cycloadditions; 3.5 Asymmetric Processes Stereocontrolled by Remote Sulfoxides; 3.5.1 Nucleophilic Processes; 3.5.1.1 Reactions with Sulfinylated Electrophiles |
3.5.1.2 Reactions with Sulfinylated Nucleophiles3.6 Asymmetric Pummerer Reaction; References; 4 Synthesis and Applications of Chiral Dithioacetal Derivatives; 4.1 Introduction; 4.2 Lithiated Dithianes; 4.3 Alternative Methods; 4.4 Oxidation Methods for the Construction of Chiral Dithioacetal Derivatives and Applications in Synthesis; 4.5 Applications of Chiral Dithioacetal Derivatives in Natural Product and Biologically Active Compound Synthesis; 4.6 Summary; References; 5 Synthesis and Use of Chiral Sulfur Ylides; 5.1 Introduction; 5.1.1 Reactions of Sulfonium Ylides |
5.1.2 Methods of Preparation |
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Sommario/riassunto |
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In this first book to gather the information on this hot topic otherwise widely spread throughout the literature, experienced editors and top international authors cover everything the reader needs -- from the synthesis of chiral organosulfur compounds to applications and catalysis: * Asymmetric synthesis of chiral sulfinates and sulfoxides* Synthesis and use of chiral dithioacetal derivatives, ylids, chiral sulfoximines and sulfinamides* Use of chiral sulfoxides as ligands in catalysis* Asymmetric reactions of alpha-sulfenyl, alpha-sulfinyl and alpha-sulfonyl carbanions.As |
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