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Record Nr. |
UNINA9911019855503321 |
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Titolo |
Biology of IGF-1 : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode] |
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Pubbl/distr/stampa |
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The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
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ISBN |
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9786610272518 |
9781280272516 |
1280272511 |
9780470667538 |
0470667532 |
9780470869970 |
0470869976 |
9780470869994 |
0470869992 |
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Descrizione fisica |
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1 online resource (294 p.) |
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Collana |
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Novartis Foundation symposium ; ; 262 |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Somatomedin - Physiological effect |
Somatomedin - Pathophysiology |
Carcinogenesis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- |
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