Biomedical applications / / edited by Alaa S. Abd-El-Aziz ... [et al.]

• Record Nr.: UNINA9911019806903321
• Pubbl/distr/stampa: Hoboken, NJ, : Wiley-Interscience, c2004
• ISBN: 9786610542161; 9781280542169; 1280542160; 9780471683759; 0471683752; 9780471683773; 0471683779
• Descrizione fisica: 1 online resource (234 p.)
• Collana: Macromolecules containing metal and metal-like elements, , 1545-438X ; ; v. 3
• Altri autori (Persone): Abd-El-AzizAlaa S
• Disciplina: 547.7; 610/.28
• Soggetti: Polymers in medicine; Macromolecules; Organometallic compounds
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Macromolecules Containing Metal and Metal-Like Elements Volume 3; Contributors; Contents; Preface; Series Preface; 1. Organometallic Compounds in Biomedical Applications; I. Introduction; II. Case for Metal-Containing Bioactive Agents; A. Tin-Containing Biocidal Polymers; B. Ferrocene: A Therapeutic Role in Polymeric Systems?; C. Polymeric Moderation of OsO(4) Toxicity; III. Miscellaneous Polymers; A. Metal Chelation Polymers; B. Condensation Polymers; IV. Small-Molecule Analogs; V. Summary; VI. References; 2. Metal-Labeled DNA on Surfaces; I. Introduction; II. Ferrocene Nucleotides; III. Ferrocene-DNA ConjugatesIV. Other Metal-DNA Conjugates; V. Metallated DNA; A. Cu-DNA; B. M-DNA; VI. Summary; VII. Acknowledgments; VIII. References; 3. Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly; I. Introduction; II. Alternative Hydrogen-Bonding Schemes for DNA Base ; Pairing; III. Non-Hydrogen-Bonding Basepairs in DNA; IV. Metal-Mediated Base Pairing in DNA; A. Basic Concept; B. Artificial Nucleosides Designed for Metal-Mediated Base Pairs; C. Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal Stability; D. Discrete Self-Assembled Metal Arrays in DNAV. Future Prospects for Artificial Metallo-DNA; VI. Summary; VII. References; 4. Organotin Macromolecules as Anticancer Drugs; I. General; II. Anticancer Activity of Small Organotin Compounds; III. Molecule-Level Studies on Monomeric Organotin Compounds; IV. Anticancer Activity of Organotin Polymers; V. Future Work; VI. References; 5. Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir; I. Early History of Organotin Compounds; II. Mechanisms and Reactions; III. General Structures; IV. Acyclovir; V. Bioactivity of Related Compounds; VI. Experimental WorkVII. Results and Discussion; VIII. References; 6. Polymeric Ferrocene Conjugates as Antiproliferative Agents; I. Introduction; II. The Ferrocene-Ferricenium System in the Biological Environment; III. Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery; IV. Polymer-Ferrocene Conjugates: Synthesis and Structure; A. The Carrier Component: Structural Considerations; B. Conjugates of Amide-Linked Ferrocene; C. Conjugates of Ester-Linked Ferrocene; V. Bioactivity Screening; VI. Summary and Conclusions; VII. Acknowledgments; VIII. References; 7. Polymeric Platinum-Containing Drugs in the Treatment of CancerI. Introduction; II. Basic Mechanisms of Pt(II) Complex Formation; III. Nomenclature; IV. Currently Approved Platinum-Containing Compounds; V. Properties of Cisplatin; VI. Structure-Activity Relationships; VII. Polymer-Drug Conjugation Strategy and Possible Benefits; A. Polymers as Carriers; B. Polymers as Drugs; C. General; VIII. Mainchain-Incorporated cis-Diamine-Coordinated Platinum; A. Simple Amine Derivatives; B. Amino Acid Derivatives; C. Other Nitrogen-Platinum Products; D. Solution Stability; E. Thermal Stability; F. Antiviral Activity
• Sommario/riassunto: Metal and metalloid-containing compounds exhibit a wide range of biological and biocidal activities, some of which have been employed in medicines and drugs. Polymers containing metal or metalloid functions become a natural extension of this effort; just as organic compound drugs have been chemically bound to polymers or physically imbibed into polymer matrices in order to provide a variety of useful advantages, the same opportunities exist for using metal and metalloid species. This volume will cover important biomedical applications of organometallic compounds, including metal-labeled DNA on