Vascular development / / [editors : Derek J. Chadwick and Jamie Goode]

• Record Nr.: UNINA9911019759703321
• Pubbl/distr/stampa: Chichester, : Wiley, c2007
• ISBN: 9786611032050; 9781281032058; 1281032050; 9780470319413; 0470319410; 9780470319420; 0470319429
• Descrizione fisica: 1 online resource (262 p.)
• Collana: Novartis Foundation Symposium ; ; 283
• Altri autori (Persone): ChadwickDerek; GoodeJamie
• Disciplina: 573.12138; 612.13
• Soggetti: Blood-vessels - Growth; Cardiovascular system
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Symposium on Vascular development held at the Novartis Foundation, London 13-15 June 2006"--p. v.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Vascular Development; Contents; Chair's introduction; The control of endothelial cell functions by adherens junctions; DISCUSSION; The role of Egfl7 in vascular morphogenesis; DISCUSSION; A model of intussusceptive angiogenesis; DISCUSSION; Vascular lumen formation from a cell biological perspective; DISCUSSION; The genetics of vasculogenesis; DISCUSSION; Negative regulators of vessel patterning; DISCUSSION; Lymphangiogenesis in development and disease; DISCUSSION; Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis; DISCUSSION; HIF in vascular development andtumour angiogenesisDISCUSSION; Imaging the developing lymphatic system using the zebrafish; DISCUSSION; Signalling pathways regulating cardiac neural crest migration and differentiation; DISCUSSION; Investigation of the angiogenic programme with tissue-specific and inducible genetic ; approaches in mice; DISCUSSION; Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity; DISCUSSION; Growth factor gradients in vascular patterning; DISCUSSION; Endothelial cell promotion of early liver and pancreas development; DISCUSSION; Embryonic development and malformation of lymphatic vesselsDISCUSSION; Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse; DISCUSSION; FINAL DISCUSSION; Tracheal tube development in Drosophila; Closing remarks; Contributor Index; Subject Index
• Sommario/riassunto: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while,