Autophagy in immunity and infection : a novel immune effector / / edited by Vojo Deretic

• Record Nr.: UNINA9911019734803321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, c2006
• ISBN: 9786610723560; 9781280723568; 1280723564; 9783527608805; 352760880X; 9783527608546; 3527608540
• Descrizione fisica: 1 online resource (288 p.)
• Altri autori (Persone): DereticVojo
• Disciplina: 616.07/9
• Soggetti: Phagocytosis
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Autophagy in Immunity and Infection; Contents; Preface; Foreword; List of Contributors; Color Plates; Part I Introduction to Autophagy; 1 Overview of Autophagy; 1.1 Overview of Autophagy; 1.2 The Discovery of Autophagy; 1.3 Mechanistic Aspects of Autophagy; 1.3.1 Induction; 1.3.2 Cargo Selection and Packaging; 1.3.3 Vesicle Nucleation; 1.3.4 Vesicle Expansion and Completion; 1.3.5 Retrieval; 1.3.6 Targeting, Docking and Fusion of the Vesicle with the Lysosome/Vacuole; 1.3.7 Breakdown of the Vesicle and its Cargo; 1.4 Autophagy and Immunity; References; 2 Cell Biology and Biochemistry of Autophagy2.1 Introduction; 2.2 Autophagic Pathway; 2.2.1 Formation of Autophagosomes; 2.2.2 Fusion of AV with Endocytic Pathways and Maturation; 2.2.3 Endosomes and Lysosomes; 2.3 Regulation of Mammalian Autophagy by Amino Acids and Hormones; 2.3.1 Amino Acids; 2.3.2 Hormones; 2.3.3 Longer-term Regulation; 2.3.4 The Nutrient Sensor Target of Rapamycin (TOR); 2.3.5 Upstream of TOR; 2.3.6 Downstream of TOR; 2.4 Methods to Measure Autophagy; 2.4.1 Microscopic Methods; 2.4.1.1 Electron Microscopy; ; 2.4.1.2 Light Microscopy; 2.4.2 Biochemical Methods; 2.4.2.1 Formation and Induction2.4.2.2 Fusion; 2.4.2.3 Purification of Autophagosomes from Rat Liver; 2.4.2.4 Inhibition of Autophagy; 2.4.2.5 Common Questions; 2.4.3 Summary and Outlook; References; 3 Transgenic Models of Autophagy; 3.1 Molecular Mechanism of Mammalian Autophagy; 3.1.1 Atg12 Conjugation System; 3.1.2 Atg8/Microtubule-associated Protein 1 Light Chain 3 (LC3) Conjugation System; 3.1.3 Class III Phosphatidylinositol-3-kinase (PI3K) Complex; 3.1.4 Atg1 Kinase Complex; 3.1.5 Other Factors; 3.2 Autophagy Indicator Mice: Green Fluorescent Protein (GFP)-LC3 Transgenic Mice; 3.3 Mouse Models Deficient for Autophagy-related Genes3.3.1 Atg5-deficient Mice; 3.3.2 Atg7-deficient Mice; 3.3.3 Beclin 1-deficient Mice; 3.4 Concluding Remarks; References; 4 Autophagy in Disease and Aging; 4.1 Introduction; 4.2 Autophagy in Neurodegenerative Disorders; 4.2.1 Protein Misfolding and Aggregation; 4.2.2 Parkinson's Disease; 4.2.3 Alzheimer's Disease; 4.2.4 Huntington's Disease; 4.2.5 Prion Diseases; 4.2.6 Niemann-Pick Type C; 4.3 Autophagy and Cancer; 4.3.1 Proteolysis of long-lived Proteins and Effect of Nutrient Deprivation in Cancer Cells; 4.3.2 Autophagic Cell Death in Response to Anticancer Treatment4.3.3 Molecular Mechanisms; 4.3.3.1 Beclin 1; 4.3.3.2 PI3K-Akt-mTOR Pathway; 4.3.4 Possible Therapeutic Attempts; 4.4 Myopathies; 4.4.1 Danon Disease; 4.4.2 XMEA; 4.4.3 Rimmed Vacuolar Myopathies; 4.4.4 Other Myopathies; 4.4.5 Cardiomyopathies and Myocardial Cell Death; 4.5 Liver Diseases; 4.6 Diabetes Mellitus; 4.7 Aging; 4.7.1 Changes in Protein Degradation with Age; 4.7.2 Age-related Changes in Autophagy; 4.7.3 Consequences of the Failure of Autophagy in Aging; 4.7.4 Slowing Down Aging?; 4.8 Concluding Remarks and Pending Questions
• Sommario/riassunto: This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.