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1. |
Record Nr. |
UNINA9911019999603321 |
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Titolo |
Apicomplexan parasites : molecular approaches toward targeted drug development / / edited by Katja Becker |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-Blackwell, c2011 |
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ISBN |
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1-283-83537-1 |
3-527-63389-8 |
3-527-63388-X |
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Edizione |
[4th ed.] |
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Descrizione fisica |
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1 online resource (552 p.) |
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Collana |
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Drug discovery in infectious diseases ; ; v. 2 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Antiprotozoal agents |
Protozoan diseases - Chemotherapy |
Apicomplexa |
Drug development |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development; Foreword; Contents; Preface; List of Contributors; Part One: Screening, Bioinformatics, Chemoinformatics, and Drug Design; 1 Drug Discovery Approaches Toward Anti-Parasitic Agents; 2 New Bioinformatic Strategies Against Apicomplexan Parasites; 3 Sorting Potential Therapeutic Targets in Apicomplexa; 4 Alternatives to Drug Development in the Apicomplexa; Part Two: Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches; 5 Energy Metabolism as an Antimalarial Drug Target |
6 Polyamines in Apicomplexan Parasites7 The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug; 8 Lipids as Drug Targets for Malaria Therapy; 9 Targeting Apicoplast Pathways in Plasmodium; 10 Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites; 11 Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation; 12 Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets; 13 Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein-Protein Interaction |
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14 Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen CryptosporidiumPart Three: Drug Targets in Apicomplexan Parasites; 15 Novel Apicomplexan Phosphatases and Immunophilins as Domain-Specific Drug Targets; 16 Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets; 17 Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites; 18 Protein Acylation: New Potential Targets for Intervention Against the Apicomplexa; 19 Drugs and Drug Targets in Neospora caninum and Related Apicomplexans; Part Four: Compounds |
20 Subversive Substrates of Glutathione Reductases from Plasmodium falciparum-Infected Red Blood Cells as Antimalarial Agents21 Ferroquine: A Concealed Weapon; 22 Current Aspects of Endoperoxides in Antiparasitic Chemotherapy; 23 Plasmodium Hsp90 as an Antimalarial Target; 24 Drug Discovery Against Babesia and Toxoplasma; 25 Search for Drugs and Drug Targets against Babesia bovis, Babesia bigemina, Babesia caballi, and Babesia (Theileria) equi; 26 Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites?; 27 Recent Drug Discovery Against Cryptosporidium; Index |
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Sommario/riassunto |
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This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book seri |
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2. |
Record Nr. |
UNINA9911019718303321 |
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Titolo |
GPRS networks / / Geoff Sanders ... [et al.] |
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Pubbl/distr/stampa |
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Chichester, England ; ; Hoboken, NJ, : Wiley, c2003 |
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ISBN |
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9786610272419 |
9781280272417 |
1280272414 |
9780470340394 |
0470340398 |
9780470869543 |
0470869542 |
9780470869550 |
0470869550 |
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Descrizione fisica |
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1 online resource (306 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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General Packet Radio Service |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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GPRS Networks; Contents; Preface; Introduction; 1 Mobile Radio Evolution; 1.1 Trend from Speech to Data Transmission; 1.2 The Third Generation; 1.3 GSM - The Global System for Mobile Communications; 1.4 GSM - Evolutionary Concept; 1.5 The Standards; 2 The General Packet Radio Service; 2.1 GPRS Objectives and Advantages; 2.2 GPRS Architecture; 2.3 Characteristics of a GPRS Connection; 2.4 Logical Functions; 3 Interfaces and Protocols; 3.1 Introduction; 3.2 Layer Model; 3.3 The Names of the GPRS Interfaces; 3.4 GPRS Procedures; 3.5 GPRS Attach; 3.6 Activation of a PDP Context; 3.7 Data Transfer |
3.8 Physical Implementation in the GPRS Network3.9 GPRS Signalling; 3.10 GPRS Protocol Planes; 4 GPRS Procedures; 4.1 GPRS Mobility Management Procedures; 4.2 Session Management Procedures; 4.3 Packet Transfer Procedures; 5 Changes in the Radio Subsystem for GPRS; 5.1 Overview and Key Architecture; 5.2 Introduction of EDGE, ECSD and E-GPRS; 6 Core Network; 6.1 Serving GPRS Support Node |
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(SGSN); 6.2 Gateway GPRS Support Node (GGSN); 6.3 Access Network PCU - SGSN (Gb Interface); 6.4 Core Network SGSN, GGSN (Gn Interface); 6.5 Additional Elements in the Core Network |
6.6 Additional Elements at the Gi Interface6.7 Connections Towards the GSM Network; 7 Terminal Equipment; 7.1 Types of Terminal Equipment; 7.2 Multi-slot Classes and GPRS MS Classes; 7.3 The Settings in a GPRS-enabled Mobile Device; 8 Planning and Dimensioning; 8.1 Introduction; 8.2 Network Dimensioning; 8.3 GPRS Radio Subsystem; 8.4 GPRS Core Network; 8.5 User Aspects; 8.6 Indoor Radio Networks; 9 Towards All-IP Networks; 9.1 The TCP/IP Protocol Suite; 9.2 Convergence of Fixed, Mobile and Data Networks; 9.3 The Roles of GSM, GPRS and UMTS in Converged Networks; 10 Applications; 10.1 Services |
10.2 Multimedia Messaging Service (MMS)10.3 GSM-R; 10.4 m-Business and m-Commerce; 11 Roaming and GRX; 11.1 Introduction; 11.2 Why do we need Roaming in GPRS?; 11.3 Architecture; 11.4 GPRS Roaming eXchange (GRX) Network; 11.5 Procedures; 11.6 Quality Aspects of GRX; Glossary and Abbreviations; Index |
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Sommario/riassunto |
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GPRS is a packet based wireless communication service that offers data rates from 9.05 up to 171.2 Kbps and continuous connection to the Internet for mobile phone and computer users. GPRS is based on GSM communications and complements existing services such as circuit switched cellular phone connections and the Short Message Service (SMS).GPRS represents the bridge between 2G and 3G mobile telecommunications and is commonly referred to as 2.5G. Implementation of GPRS requires modification of the existing GSM networks in that GSM is a circuit switched technology while GPRS is packet orien |
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