Ciba Foundation Symposium on the Chemistry and Biology of Purines / / editors for the Ciba Foundation, G.E.W. Wolstenholme and Cecilia M. O'Connor

• Record Nr.: UNINA9911019466403321
• Pubbl/distr/stampa: Boston, : Little, Brown and Co., [1957]
• ISBN: 9786613679321; 9781280768552; 128076855X; 9780470719015; 047071901X; 9780470716489; 0470716487
• Descrizione fisica: 1 online resource (350 p.)
• Collana: Ciba Foundation symposia
• Altri autori (Persone): WolstenholmeG. E. W (Gordon Ethelbert Ward); O'ConnorCecilia M <1927-> (Cecilia Mary)
• Disciplina: 612.015
• Soggetti: Purines
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: CHEMISTRY AND BIOLOGY OF PURINES; CONTENTS; Opening remarks; Synthesis and properties of purines of potential biological interest; Discussion; Some synthetic studies on purines and related heterocycles; Discussion; Some new -N-methylpurines; The structure of the hydroxypurines investigated by O-and N-methylation; Discussion; The spectra and structure of the monohydroxypurines and other potentially tautomeric purines; Short Communication; The p-electron properties of purine calculated by the L.C.A.O. method; Discussion; The degradation of uric acid by water under pressure; The 8-position in purines. The chemical and biological transformation of purines into pteridines Discussion; Cvclonucleosides; Discussion; Stereochemistry of nucleoside synthesis; Discussion; Synthetic chemical investigations related to the metabolism of purines; Discussion; The effects of potential antipurines on a purine-requiring strain of Escherichla coli; Discussion; The chemistry of new purines in the B12 ; series of vitamins; Biological and microbiological activity of purine analogues of vitamin B12; Discussion; Puromycin; Discussion; Chemical and biological behaviours of 9-b-D-ribofuranosylpurine Discussion; On the activation of the one-carbon unit for the biosynthesis of purine nucleotides; The enzymatic synthesis of inosinic acid de novo; Discussion; Enzymic control of purines by xanthine oxidase; Discussion; The biological effects of 8-azapurines; Discussion; Biochemical effects of 6-mercaptopurine; Discussion; The use of 6-mercaptopurine in the treatment of leukemia; Discussion; General Discussion; Chairman's closing remarks
• Sommario/riassunto: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.