Molecular clocks and light signalling / / [editors, Derek J. Chadwick and Jamie A. Goode]

• Record Nr.: UNINA9911019437303321
• Pubbl/distr/stampa: Chichester, UK ; ; Hoboken, NJ, : Wiley, 2003
• ISBN: 9786610269075; 9781280269073; 1280269073; 9780470090824; 0470090820; 9780470090831; 0470090839
• Descrizione fisica: 1 online resource (308 p.)
• Collana: Novartis Foundation symposium ; ; 253
• Altri autori (Persone): ChadwickDerek; GoodeJamie
• Disciplina: 571.4; 571.7/7; 571.77
• Soggetti: Circadian rhythms; Photobiochemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Held at the Novartis Foundation, London, 3-5 September 2002"--p. v.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: MOLECULAR CLOCKS AND LIGHT SIGNALLING; Contents; Participants; Chair's introduction; Non-rod, non-cone photoreception in rodents and teleost fish; Discussion; Cryptochromes and inner retinal non-visual irradiance detection; Discussion; General discussion I; Light signalling in Cryptochrome-deficient mice; Discussion; Circadian light input in plants, flies, and mammals; Discussion; Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators; Discussion; General discussion; SCN: ringmaster of the circadian circus or conductor of the circadian orchestra?; DiscussionOn the communication pathways between the central pacemaker and peripheral oscillators; Discussion; Central and peripheral circadian oscillators in Drosophila; Discussion; Integration of ; molecular rhythms in mammalian circadian system; Circadian transcriptional output in the SCN and liver of the mouse; Discussion; The molecular workings of the Neurospora biological clock; Discussion; Expression of clock gene products in the suprachiasmatic nucleus in relation to circadian behaviour; Discussion; Circadian rhythms in Drosophila; Discussion; The role of phosphorylation and degradation of hPer proteins oscillation in normal human fibroblastsDiscussion; Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling; Discussion; CK1 and GSK-3 in the Drosophila and mammalian circadian clock; Discussion; Final general discussion; Closing remarks; Index of contributors; Subject index
• Sommario/riassunto: The ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability to entrain to environmental stimuli. The dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. The exact identity of the molecules involved in circadian photoreception has remained elusive. The classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. This book present