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1. |
Record Nr. |
UNINA990009052740403321 |
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Titolo |
Romanobarbarica |
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Pubbl/distr/stampa |
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Roma, : Herder editrice e libreria |
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ISSN |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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2. |
Record Nr. |
UNINA9911019395903321 |
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Autore |
Saintome Carole |
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Titolo |
Telomeres : Chromosome Sentinels |
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Pubbl/distr/stampa |
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Newark : , : John Wiley & Sons, Incorporated, , 2024 |
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©2024 |
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ISBN |
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9781394300808 |
1394300808 |
9781394300785 |
1394300786 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (399 pages) |
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Disciplina |
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Soggetti |
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Telomere |
Molecular biology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Chapter 1. Telomeres: All's Well That Ends Well -- 1.1. Introduction -- 1.2. The beginning of the end -- 1.2.1. Chemists and biophysicists at work: G-quartets and G-quadruplexes disclose themselves -- 1.2.2. Biologists at work: telomeres disclose themselves -- 1.2.3. When and where G-quadruplexes and telomeres met -- 1.3. Telomeric |
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architectures: from ciliates to other eukaryotes -- 1.3.1. Telomeric DNA and telomeric proteins -- 1.3.2. Telomeric structures -- 1.4. G-quadruplexes at telomeres -- 1.4.1. Secondary structures formed by repeats of telomeric motifs -- 1.4.2. G4s at telomeres: friendly or unfriendly structures? -- 1.5. References -- Chapter 2. Methods to Measure Telomere Lengths -- 2.1. Why does telomere length matter? -- 2.2. Methods for measuring telomere length -- 2.2.1. Terminal restriction fragment analysis (TRF) -- 2.2.2. Single telomere length analysis -- 2.2.3. Telomere shortest length assay -- 2.2.4. Quantitative-polymerase chain reaction -- 2.2.5. Quantitative-fluorescence in situ hybridization -- 2.2.6. Flow-fluorescence in situ hybridization -- 2.3. References -- Chapter 3. The Shelterin Complex -- 3.1. TRF1 and TRF2, structurally alike but… -- 3.1.1. Domains organization -- 3.1.2. Biological roles -- 3.2. RAP1 -- 3.3. TIN2 -- 3.4. TPP1-POT1 -- 3.5. Quaternary structure of the shelterin -- 3.6. Concluding remarks -- 3.7. References -- Chapter 4. Mammalian Telomere Organization and Dynamics in the Nuclear Volume -- 4.1. Introduction -- 4.2. Nuclear envelope and lamins: orchestrators of cell and genome architecture -- 4.2.1. The nuclear envelope landmarks -- 4.2.2. The nuclear envelope as a scaffold to organize nuclear architecture -- 4.2.3. Nuclear envelope disassembly during mitosis -- 4.3. Interplay between telomeres and nuclear structures. |
4.4. Telomere tethering to the NE to promote meiotic pairing -- 4.5. Telomere organization and dynamics in the nucleus -- 4.6. Interaction between telomere chromatin and lamins during post-mitotic nuclear assembly -- 4.7. Interaction between telomere chromatin and lamins for telomere maintenance -- 4.8. Conclusion -- 4.9. References -- Chapter 5. Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology -- 5.1. Introduction -- 5.2. Telomere characterization: various experimental organisms for first historical experiments -- 5.3. Protection and proliferation: the telomere dilemma -- 5.3.1. Telomeric sequences: pattern conservation and length variations -- 5.3.2. Telomeric proteins -- 5.3.3. TERRA or telomere transcription -- 5.4. Telomere maintenance -- 5.4.1. The difficulties of moving replication fork through telomeres -- 5.4.2. The end replication problem -- 5.4.3. Telomerase: a solution to the problem of telomere shortening -- 5.5. Telomeres: one size for one identity -- 5.6. Telomeres, replicative senescence, aging and genomic instability -- 5.6.1. Aging and replicative senescence -- 5.6.2. Heterogeneity of senescence at the single cell level -- 5.7. Senescence escape phenomena and genomic instability -- 5.8. Conclusion -- 5.9. References -- Chapter 6. Dealing with Replication Stress at Telomeres -- 6.1. Introduction -- 6.1.1. Telomere, telomerase and shelterin -- 6.1.2. Aging, cancer and telomere syndromes -- 6.1.3. The telomere replication problem -- 6.2. Removal of the DNA structures that impede RF progression -- 6.2.1. G-quadruplex dissolution by helicases -- 6.2.2. G-quadruplex dissolution by single-strand binding proteins -- 6.2.3. T-loop dissolution -- 6.2.4. RNA:DNA hybrid removal -- 6.2.5. Topological constraints -- 6.3. Accessory factors that contribute to telomere replication l -- 6.3.1. The CST complex. |
6.3.2. The MRN complex and CtIP -- 6.3.3. SLX4 -- 6.3.4. Timeless and AKTIP -- 6.3.5. RECQL helicases and SMARCAL1 translocase -- 6.4. Concluding remarks -- 6.5. References -- Chapter 7. A Brief History of Telomerase: Exceptional Women in Command -- 7.1. Acknowledgments -- 7.2. References -- Chapter 8. Telomerase: Structure and Mechanism -- 8.1. Introduction -- 8.2. Roles -- 8.3. Structures -- 8.3.1. The catalytic core -- 8.3.2. The holoenzyme -- 8.4. Biogenesis -- 8.5. Mechanism -- 8.6. Regulation -- 8.7. Disease |
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and therapy -- 8.8. Conclusion -- 8.9. References -- Chapter 9. Alternative Lengthening of Telomeres -- 9.1. ALT cell markers -- 9.1.1. ALT telomeres are associated with PML bodies: APBs -- 9.1.2. Telomeres of heterogeneous size -- 9.1.3. The accumulation of extra-chromosomal circular telomeric DNA -- 9.1.4. Variant telomeric DNA repeats -- 9.1.5. Sister chromatid exchange at telomeres -- 9.1.6. The accumulation of TERRA -- 9.1.7. Loss of function of the ATRX signaling pathway -- 9.2. ALT mechanisms -- 9.3. Replicative stress and DNA repair pathway at ALT telomeres -- 9.4. The structure of chromatin at ALT telomeres -- 9.5. ALT and cancer -- 9.6. The ALT pathway: a non-pathological function? -- 9.7. Alternative pathways not involving recombination: evolutionary aspects -- 9.8. Appendix: experimental methods that allow the identification of the ALT phenotype in human cancer cells -- 9.9. References -- Chapter 10. TERRA, Telomeric Non-coding RNAs -- 10.1. Introduction -- 10.2. The human TERRAs -- 10.2.1. The majority of human telomeres are transcribed -- 10.2.2. Telomere length influences human TERRAs -- 10.2.3. Induction of human TERRA expression by different types of stress: metabolic, oxidative stress, heat shock or DNA damage -- 10.2.4. Human TERRAs form RNA:DNA hybrids at telomeres to form R-loops. |
10.2.5. Other known functions of human TERRAs -- 10.3. The mouse TERRAs -- 10.3.1. The majority of murine telomeres are probably not transcribed -- 10.3.2. PAR-TERRA: a crucial role in homologous sex chromosome pairing and in the regulation of ATRX target gene expression -- 10.3.3. Known or predicted functions of murine TERRAs -- 10.4. Conclusion -- 10.5. References -- Chapter 11. Telomeres and Cancer -- 11.1. Introduction -- 11.2. Short telomeres and telomere-induced senescence are barriers to oncogenic development -- 11.3. Excessive shortening of telomeres promotes CIN in the early stages of cancer transformation -- 11.4. The contribution of telomere-driven CIN to tumor progression -- 11.5. The senescent microenvironment promotes cancer development -- 11.6. Mechanisms of cell immortalization -- 11.7. Therapeutic potential of telomeres and telomerase and prognostic value of telomere-related evaluations -- 11.8. Conclusion -- 11.9. Acknowledgments -- 11.10. References -- Chapter 12. Physiopathology of Telomeres -- 12.1. Introduction -- 12.2. Telomere length in blood -- 12.2.1. Measurement of telomere length -- 12.2.2. Telomere length in patients with telomeropathy -- 12.3. Different genes associated with telomere defects -- 12.3.1. Telomerase complex -- 12.3.2. Shelterin complex -- 12.3.3. CST complex (CTC1/STN1/TEN1) -- 12.3.4. Telomere stability factor -- 12.4. Different diseases associated with telomere defects -- 12.4.1. Dyskeratosis congenita (DC) -- 12.4.2. Hoyeraal-Hreidarsson (HH) syndrome -- 12.4.3. The Revesz syndrome -- 12.4.4. Coats plus syndrome -- 12.4.5. Bone marrow failure -- 12.4.6. Lung disease -- 12.4.7. Liver disease -- 12.4.8. Other clinical impairments -- 12.5. Genetic analysis and counseling -- 12.5.1. Genetic analysis of telomeropathies -- 12.5.2. Genetics of telomeropathies. |
12.5.3. Telomeropathy genetic counseling in practice, management of rare diseases in France -- 12.5.4. Epigenetic heritability -- 12.6. Treatment of diseases associated with telomere defects -- 12.7. Compensatory somatic mutations in the TERT promoter -- 12.8. Missing heredity -- 12.9. Conclusion -- 12.10. References -- Chapter 13. Telomeres Targeting Agents -- 13.1. Introduction -- 13.2. Chemistry and in vitro properties of G4 ligands targeting telomeres -- 13.2.1. Condensed heteroaromatics: the first generations -- 13.2.2. Macrocyclic polyheteroaryles -- 13.2.3. Bisquinolinium and bisquinoline compounds with an aromatic dicarboxamide core |
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(triazines, 360A, PhenDC3, PDS) -- 13.2.4. Alternative hybrid scaffolds derived from the series above -- 13.2.5. Telomeric localization of G4 ligands through imaging -- 13.3. Biological properties of G4 ligands targeting telomeres -- 13.4. Metal complexes targeting telomeres -- 13.5. Compounds targeting the proteins of the human shelterin complex -- 13.5.1. Inhibitors of the shelterin proteins binding to DNA -- 13.5.2. Inhibitors of protein-protein interactions involving the shelterin proteins -- 13.5.3. Chemical modulators of the shelterin proteins -- 13.6. Compounds targeting telomerase -- 13.6.1. Oligonucleotides as telomerase inhibitors -- 13.6.2. Small molecule as inhibitors of telomerase -- 13.6.3. Biologics as inhibitors of telomerase -- 13.7. General conclusion -- 13.8. Acknowledgments -- 13.9. References -- List of Authors -- Index -- EULA. |
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Sommario/riassunto |
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This book, coordinated by Carole Saintomé, delves into the scientific study of telomeres, the protective structures at the ends of chromosomes. It explores their role in cellular biology, including their structural characteristics, biological functions, and the methods used to measure their lengths. The book discusses the shelterin complex and its components, which play a critical role in telomere maintenance and stability. The text is aimed at researchers and students in the fields of molecular biology, biochemistry, and structural biology, offering insights into telomeric DNA and protein interactions as well as the dynamics of telomeres within the nuclear environment. |
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