Plasminogen-related growth factors / / [editors, Gregory R. Bock (organizer) and Jamie A. Goode]

• Record Nr.: UNINA9911019310403321
• Pubbl/distr/stampa: Chichester ; ; New York, : Wiley, 1997
• ISBN: 9786612455445; 9781282455443; 1282455443; 9780470515457; 0470515457; 9780470515471; 0470515473
• Descrizione fisica: 1 online resource (272 p.)
• Collana: Ciba Foundation symposium ; ; 212
• Altri autori (Persone): BockGregory; GoodeJamie
• Disciplina: 571.8/4; 571.84; 573.15921
• Soggetti: Growth factors; Plasminogen; Plasminogen activators
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Symposium on plasminogen-related growth factors was held at the Ciba Foundation, London, Apr. 8-10, 1997.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: PLASMINOGEN-RELATED GROWTH FACTORS; Contents; Participants; Chairman's introduction; Evolution of vertebrate fibrin formation and the process of its dissolution; Evolution of plasminogen-related growth factors (HGF/SF and HGFl/MSP); General discussion I; The kringle domains of human plasminogen; Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments; Domain structure of hepatocyte growth factor/scatter factor (HGF/SF); General discussion II; Plasminogen/plasminogen activator and growth factor activation; Met-HGF/SF: tumorigenesis, invasion and metastasisScatter factor ; receptors are key players in a unique multistep program leading to invasive growth; General discussion III; Competence for neural induction: HGF/SF, HGFl/MSP and the c-Met receptor; The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development; Biological aspects of macrophage- stimulating protein (MSP) and its receptor; HGF: its organotrophic role and therapeutic potential; HGF/SF in angiogenesis; Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells; General discussion IV; Chairman's summing-upIndex of contributors; Subject index
• Sommario/riassunto: A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.