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Record Nr. |
UNINA9911019305503321 |
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Titolo |
P2 purionoceptors : localization, function and transduction mechanisms |
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Pubbl/distr/stampa |
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Chichester, : Wiley, 1996 |
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ISBN |
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9786612347962 |
9781282347960 |
1282347969 |
9780470514900 |
0470514906 |
9780470514917 |
0470514914 |
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Descrizione fisica |
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1 online resource (350 p.) |
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Collana |
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Ciba Foundation symposium ; ; 198 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Purines - Receptors |
Adenosine triphosphate - Receptors |
Neurotransmitter receptors |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Editors: Derek J. Chadwick (organizer) and Jamie A. Goode. |
Symposium held at Ciba Foundation, London, 11-13 July 1995. |
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Nota di contenuto |
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P2 PURINOCEPTORS: LOCALIZATION, FUNCTION AND TRANSDUCTION MECHANISMS; Contents; Participants; P2 purinoceptors: historical perspective and cIassification; The diadenosine polyphosphate receptors: P2D purinoceptors; P2T purinoceptors: ADP receptors on platelets; P2Z purinoceptors; P2X receptors: a third major class of Iigand-gated ion channels; P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes; Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal tranduction mechanisms |
Trophic roles of P2 purinoceptors in central nervous system astroglial cellsTransduction mechanisms of P2Z purinoceptors; The diverse series |
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of recombinant P2Y purinoceptors; General discussion I; P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis; Functional properties of native and cloned P2X receptors; ATP as a co-transmitter with no rad ren al i ne i n sym pat he t i c nerves-function and fate; ATP release and its prejunctional modulation; General discussion II |
Involvement of distinct receptors in the actions of extracellular uridine nucleotidesFeatures of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell?; P2 purinoceptors in the immune system; General discussion Ill; Challenges in developing P2 purinoceptor-based therapeutics; Summing-up; Index of contributors; Subject index |
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Sommario/riassunto |
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Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas. |
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