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Record Nr. |
UNINA9911019221603321 |
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Titolo |
Somatostatin and its receptors |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1995 |
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ISBN |
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9786612137938 |
9781282137936 |
128213793X |
9780470514733 |
0470514736 |
9780470514740 |
0470514744 |
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Descrizione fisica |
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1 online resource (285 p.) |
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Collana |
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Ciba Foundation symposium ; ; 190 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Somatostatin |
Somatostatin - Receptors |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Symposium on Somatostatin and its receptors, held at the Ciba Foundation, London 12-14 July 1994. |
Editors: Derek J. Chadwick (organizer) and Gail Cardew. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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SOMATOSTATIN AND ITS RECEPTORS; Contents; Participants; Introduction; Regulation of somatostatin gene transcription by cAMP; Processing and intracellular targeting of prosomatostatin-derived peptides: the role of mammalian endoproteases; Anatomical localization and regulation of somatostatin gene expression in the basal ganglia and its clinical implications; Molecular biology of somatostatin receptors; Characterization of somatostatin receptor subtypes; Regulation of somatostatin receptor mRNA expression; Transient expression of somatostatin receptors in the brain during development |
Expression of sstrl and sstr2 in rat hypothalamus: correlation with receptor binding and distribution of growth hormone regulatory peptidesInteraction of somatostatin receptors with G proteins and cellular effector systems; Somatostatin modulates voltage- dependent |
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Ca2+ channels in GH3 cells via a specific Go splice variant; A tyrosine phosphatase is associated with the somatostatin receptor1; Function and regulation of somatostatin receptor subtypes; Somatostatin receptors: clinical implications for endocrinology and oncology |
Somatostatin analogues and multiple receptors: possible physiological rolesFinal discussion; Summary; Appendix; Index of contributors; Subject index |
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Sommario/riassunto |
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This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors. |
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2. |
Record Nr. |
UNINA9910970662003321 |
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Titolo |
Juvenile crime, juvenile justice / / Joan McCord, Cathy Spatz Widom, and Nancy A. Crowell, editors |
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Pubbl/distr/stampa |
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Washington, DC, : National Academy Press, c2001 |
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ISBN |
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0-309-17235-7 |
0-309-50428-7 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (404 p.) |
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Altri autori (Persone) |
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McCordJoan |
WidomCathy Spatz <1945-> |
CrowellNancy A |
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Disciplina |
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Soggetti |
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Juvenile delinquency - United States |
Juvenile justice, Administration of - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Panel on juvenile crime: Prevention, treatment, and control, Committee on Law and Justice, and Board on Children, Youth, and Families, Commission on Behavioral and Social Sciences and Education, National Research Council, and Institute of Medicine." |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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""Cover""; ""Front Matter""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Executive Summary""; ""1 Introduction""; ""2 Patterns and Trends in Juvenile Crime and Juvenile Justice""; ""3 The Development of Delinquency""; ""4 Preventing Juvenile Crime""; ""5 The Juvenile Justice System""; ""6 Race, Crime, and Juvenile Justice: The Issue of Racial Disparity""; ""References""; ""APPENDIX A Definition of Offenses Used in Uniform Crime Reporting""; ""APPENDIX B The Indeterminacy of Forecasts of Crime Rates and Juvenile Offenses""; ""APPENDIX C Workshop Agendas"" |
""APPENDIX D Biographical Sketches""""Index"" |
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Sommario/riassunto |
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Even though youth crime rates have fallen since the mid-1990s, public fear and political rhetoric over the issue have heightened. The Columbine shootings and other sensational incidents add to the furor. Often overlooked are the underlying problems of child poverty, social disadvantage, and the pitfalls inherent to adolescent decisionmaking that contribute to youth crime. From a policy standpoint, adolescent offenders are caught in the crossfire between nurturance of youth and punishment of criminals, between rehabilitation and "get tough" pronouncements. In the midst of this emotional debate, the National Research Council's Panel on Juvenile Crime steps forward with an authoritative review of the best available data and analysis. Juvenile Crime, Juvenile Justice presents recommendations for addressing the many aspects of America's youth crime problem. This timely release discusses patterns and trends in crimes by children and adolescents-trends revealed by arrest data, victim reports, and other sources; youth crime within general crime; and race and sex disparities. The book explores desistance-the probability that delinquency or criminal activities decrease with age-and evaluates different approaches to predicting future crime rates. Why do young people turn to delinquency? Juvenile Crime, Juvenile Justice presents what we know and what we urgently need to find out about contributing factors, ranging from prenatal care, differences in temperament, and family influences to the role of peer relationships, the impact of the school policies toward delinquency, and the broader influences of the neighborhood and community. Equally important, this book examines a range of solutions: Prevention and intervention efforts directed to individuals, peer groups, and families, as well as day care-, school- and community-based initiatives. Intervention within the juvenile justice system. Role of the police. Processing and detention of youth offenders. Transferring youths to the adult judicial system. Residential placement of juveniles. The book includes background on the American juvenile court system, useful comparisons with the juvenile justice systems of other nations, and other important information for assessing this problem. |
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