Oxygen free radicals and tissue damage

• Record Nr.: UNINA9911019220303321
• Pubbl/distr/stampa: Amsterdam ; ; New York, : Excerpta Medica, 1979
• ISBN: 9780470715413; 0470715413; 9780470715109; 0470715103
• Descrizione fisica: 1 online resource (392 p.)
• Collana: Ciba Foundation symposium ; ; 65 (new ser.)
• Disciplina: 574.1/921
• Soggetti: Active oxygen in the body; Active oxygen - Toxicology; Pathology, Cellular; Radicals (Chemistry) - Physiological effect
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Oxygen Free Radicals and Tissue Damage; Contents; Chairman's introduction; The chemistry of dioxygen and its reduction products; Discussion; Hydroxyl radicals and biological damage in uitro: what relevance in uivo?; Discussion; Reaction rates of superoxide radicals with the essential amino acids; Discussion; Formation of copper-superoxide complexes; Interactions between iron metabolism and oxygen activation; Discussion; Superoxide dismutases: defence against endogenous superoxide radical; Discussion; Glutathione peroxidase: fact and fiction; Discussion; Biosynthesis of prostaglandins; DiscussionMechanisms of protection against the damage produced in biological systems by oxygen-derived radicals; Discussion; Zinc and NADPH-oxidation-dependent lipid peroxidation; Caeruloplasmin and serum antioxidant activity; Inflammatory cells and zinc; Lipid peroxidation: detection in viuo and in vitro through the formation of saturated hydrocarbon gases; Discussion; Dioxygen and the vitamin K-dependent synthesis of prothrombin; Discussion; Specific induction of pulmonary indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide; Discussion; Oxygen consumption by stimulated human neutrophilsDiscussion; Defects in the oxidative killing of microorganisms by phagocytic leukocytes; Discussion; The role of myeloperoxidase in the microbicidal activity of polymorphonuclear leukocytes; Discussion; Fertilization of sea urchin eggs; The lactoperoxidase-thiocyanate-hydrogen peroxide antibacterium system; The pulmonary and extrapulmonary effects of ozone; Discussion; The pathology and biochemistry of paraquat; Discussion; Phagocyte-produced free radicals: roles in cyto- toxicity and inflammation; Discussion; GENERAL DISCUSSION; Carbonyl groups and carcinogenesisThe identity of the superoxide radical anion species; Closing remarks; Index of contributors; Subject index
• Sommario/riassunto: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.