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1. |
Record Nr. |
UNINA9910460087903321 |
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Titolo |
Leishmania : current biology and control / / edited by Subrata Adak and Rupak Datta |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2015] |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (258 p.) |
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Disciplina |
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Soggetti |
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Leishmania |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Contributors; Current Books of Interest; Preface; 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule; miRNA-mediated gene regulation in metazoan animals; miRNA as regulator of cholesterol metabolism in mammals; Cholesterol regulates pathogenesis of Leishmania donovani; Leishmania-mediated changes in cholesterol production in mammals; miRNA expression affected by parasite; Mechanism of miRNA alteration by Leishmania; Factors important for host cell miRNA alteration during infection; miRNA as therapeutic agent |
Future of miRNA as a therapeutic agent against visceral leishmaniasis2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat; Introduction: heat shock proteins; Heat shock proteins in Leishmania spp.; Leishmania and the cell stress; The pitfalls of analogy-based assumptions; The chaperone machinery and signal transduction in Leishmania; Open questions; Future trends; Acknowledgements; 3: Role of Iron in Leishmania-Macrophage Interaction; Introduction; Aqueous chemistry and toxicity of iron; Role of iron in physiology; Role of iron in the host-parasite interaction |
Special need of iron for LeishmaniaMammalian iron homeostasis components important for sequestering iron; Regulation of cellular iron metabolism of mammalian host; Source of host iron and its acquisition |
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systems in Leishmania; Summary and future aspects; 4: Oxidative and Nitrosative Stress Response in Leishmania; Introduction; Sources of superoxide and hydrogen peroxide in Leishmania; Targets of reactive oxygen species in Leishmania; Defence against reactive oxygen species; Nitrosative stress in Leishmania; Generation of reactive nitrogen species |
Targets of reactive nitrogen species (RNS) in LeishmaniaCellular defences against nitrosative stress in Leishmania; Conclusion; Future perspectives; 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp.; Introduction; Life cycle of Leishmania spp.; Treatment of leishmaniasis; Programmed cell death (PCD); Programmed cell death in protozoan parasites; Relevance of studying cell death in Leishmania; Apoptosis in Leishmania; Natural cell death during cell cycle; Induction of cell death by anti-leishmanial drugs; Oxidative stress induced cell death |
Role of apoptotic mimicry and apoptosis in LeishmaniaAutophagy in Leishmania; Future trends; Conclusion; 6: Elucidating the Strategies of Immune Evasion by Leishmania; Introduction; Defying recognition by the host: modulation of Toll-like receptor-mediated signalling; Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases; Disarming the enemy: inhibition of host microbicidal molecules; Delaying phagosome maturation: buying time for promastigote to amastigote conversion; Creating a favourable environment: polarization of Th (T-helper cell) response |
Suppression of antigen presentation: escaping cytotoxic T-cell response |
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Sommario/riassunto |
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Every year, with an estimated 1.3 million new cases and more than 20,000 deaths, Leishmaniasis continues to be a menace in countries across the globe. With the absence of an anti-Leishmania vaccine - along with the toxicity of current anti-parasite drugs and coupled with the rapid emergence of drug resistant Leishmania strains - there remains significant challenges for disease control. This has spurred a plethora of research initiatives into parasite biology, parasite-host interaction, mechanisms of disease pathogenesis, drug development, and the molecular mechanism of drug resistance. Insight |
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2. |
Record Nr. |
UNINA9911019197503321 |
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Autore |
Kemp Paul <1972-> |
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Titolo |
Salmonid fisheries : freshwater habitat management / / Paul Kemp |
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Pubbl/distr/stampa |
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Ames, IA, : Blackwell, 2010 |
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ISBN |
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1-283-15740-3 |
9786613157409 |
1-4443-2333-4 |
1-4443-2334-2 |
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Descrizione fisica |
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1 online resource (347 p.) |
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Disciplina |
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Soggetti |
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Salmon fisheries - Management |
Trout fisheries - Management |
Salmonidae - Habitat - Conservation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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SALMONID FISHERIES; Contents; Contributors; Preface and Acknowledgements; Chapter 1 Variation in Habitat Quality for Drift-Feeding Atlantic Salmon and Brown Trout in Relation to Local Water Velocity and River Discharge; Chapter 2 'Catchment Consciousness' - Will Mantra, Metric or Mania Best Protect, Restore and Manage Habitats?; Chapter 3 In-Channel Placement of Structure to Enhance Habitat Complexity and Connectivity for Stream-Dwelling Salmonids; Chapter 4 Integrating Science and Practice for the Sustainable Management of In-Channel Salmonid Habitat |
Chapter 5 Monitoring Salmon Stream Restoration: Guidelines Based on Experience in the American Pacific NorthwestChapter 6 Restoring Ecological Connectivity in Rivers to Improve Conditions for Anadromous Brown Trout (Salmo trutta); Chapter 7 Riparian Management: Alternative Paradigms and Implications for Wild Salmon; Chapter 8 Does Fencing of British Lowland Streams Encourage Greater Salmonid Fish Stocks?; Chapter 9 Effects of Competing Brown Trout on Habitat Use by Atlantic Salmon Parr: Controlled Investigations in a Laboratory Stream |
Chapter 10 Pool Restoration for Atlantic Salmon (Salmo salar) in Gravel |
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Bed Rivers in New Brunswick, CanadaChapter 11 Nutrient Restoration Using Atlantic Salmon Carcasses as a Component of Habitat Management in Scottish Highland Streams; Chapter 12 Habitat Requirements for Juvenile Salmonids in Chalk Streams: How will Management Best Address Conflicting Interests?; Chapter 13 Aerial Photography as a Tool for Salmonid Habitat Assessment; Chapter 14 Lymington River Fish Passage Easements: A Case Study from the New Forest (UK) |
Chapter 15 A Catalyst for Trout Habitat Improvement: A Review of the Wild Trout Trust Advisory Visit ProgrammeChapter 16 Influences of Environmental Variables and Stocking on Atlantic Salmon Upstream Migrations in the River Thames, UK; Chapter 17 Managing the Effects of Climate Change: Fishery Management's Greatest Challenge; Index; Colour plates appear facing page 96 |
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Sommario/riassunto |
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Salmonid Fisheries is a landmark publication, concentrating on river management, habitat restoration and rehabilitation, disseminating lessons learnt in relation to the intensively studied salmonids that are applicable to future interventions, not just for salmonid species but for other non-salmonid species, biota and ecosystems. The contents of this book are the product of the Atlantic Salmon Trust's 40th Anniversary Conference, held in association with the Game and Wildlife Conservation Trust. Drawing together carefully-edited contributions from many of the world leaders in rive |
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