1.

Record Nr.

UNINA9911018944103321

Autore

Foundation Novartis

Titolo

The Molecular Basis of Skeletogenesis

Pubbl/distr/stampa

Hoboken, : John Wiley & Sons, Ltd., 2002

ISBN

1-280-55550-5

9786610555505

0-470-84665-8

0-470-85375-1

Edizione

[1st ed.]

Descrizione fisica

1 online resource (305 p.)

Altri autori (Persone)

CardewGail

GoodeJamie

Disciplina

573.7638199

612.7/5

Soggetti

Bones - Growth - Molecular aspects

Bone Development - genetics

Bone Development - physiology

Cartilage - embryology

Morphogenesis

Osteogenesis - genetics

Human skeletonMolecular aspects

Congress.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di contenuto

THE MOLECULAR BASIS OF SKELETOGENESIS; Contents; Introduction; Genetic control of skeletal development; Early steps in limb patterning and chondrogenesis; General discussion I; Developmental mechanisms of vertebrate limb evolution; Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3; Defects of human skeletogenesis -- models and mechanisms; Genetic control of the cell proliferation-differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways; Craniosynostosis and related limb anomalies

The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plateCartilage matrix resorption in



skeletogenesis; Retinoid signalling and skeletal development; General discussion II; Defects in extracellular matrix structural proteins in the osteochondrodysplasias; Genetic control of bone and joint formation; The molecular basis of osteoclast differentiation and activation; Clinical disorders of bone resorption; Final discussion; Index of contributors; Subject index

Sommario/riassunto

Brings together a cross-fertilization of ideas between human molecular genetics, develeopmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis.