Genetic effects on environmental vulnerability to disease / / edited by Michael Rutter

• Record Nr.: UNINA9911018923203321
• Pubbl/distr/stampa: Chicester, : Wiley-Blackwell (an imprint of John Wiley & Sons Ltd), 2008
• ISBN: 9786611840488; 9781281840486; 1281840483; 9780470696781; 0470696788; 9780470696798; 0470696796
• Descrizione fisica: 1 online resource (237 p.)
• Collana: Novartis Foundation symposium ; ; 293
• Altri autori (Persone): RutterMichael <1933->
• Disciplina: 616.042
• Soggetti: Disease susceptibility - Genetic aspects; Environmentally induced diseases - Genetic aspects
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Genetic effects on environmental vulnerability to disease; Contents; 1: Introduction: whither gene-environment interactions?; 2: Gene-environment interaction: overcoming methodological challenges; 3: Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes; 4: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory; GENERAL DISCUSSION I; 5: Role of gene-stress interactions in gene-finding studies; 6: Practice and public policy in the era of gene-environment interactions7: Gene-environment interaction and the metabolic syndrome; GENERAL DISCUSSION II; 8: Longitudinal studies of gene-environment interaction in common diseases-good value for money?; 9: Gene-environment interactions in breast cancer; 10: Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and ; outcomes of infections; 11: Gene-environment interactions in environmental lung diseases; GENERAL DISCUSSION III; 12: Gene-environment interaction in complex diseases: asthma as an illustrative case13: Conclusions: taking stock and looking ahead; Glossary; Contributor Index; Subject Index; Color Plate
• Sommario/riassunto: Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:How epidemiological cohort studies can bett