Cancer and inflammation : [Symposium on Cancer and Inflammation, held at the Novartis Foundation, London, 12-14 November 2002 / / editors, Derek J. Chadwick (organizer) and Jamie A. Goode]

• Record Nr.: UNINA9911018917003321
• Pubbl/distr/stampa: Chichester, U.K. ; ; Hoboken, N.J., : John Wiley & Sons, 2004
• ISBN: 9786610270613; 9781280270611; 1280270616; 9780470667583; 0470667583; 9780470856727; 0470856726; 9780470856734; 0470856734
• Descrizione fisica: 1 online resource (292 p.)
• Collana: Novartis Foundation symposium ; ; 256
• Altri autori (Persone): ChadwickDerek; GoodeJamie
• Disciplina: 616.99/4079
• Soggetti: Cancer - Immunological aspects; Inflammation
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: CANCER AND INFLAMMATION; Contents; Participants; Chair's introduction; Inflammation and cancer: an epidemiological perspective; Discussion; Chemokine-based pathogenetic mechanisms in cancer; Discussion; General discussion I; Anti-TNFa therapy of rheumatoid arthritis: what can we learn about chronic disease?; Discussion; How do chemokine/chemokine receptor activations affect tumorigenesis?; Discussion; Proinflammatory cytokines, immune response and tumour progression; Discussion; General discussion II; Lymphangiogenesis and tumour metastasis; Discussion; Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear ; phagocytesDiscussion; The influence of CD25(+) cells on the generation of immunity to tumour cell-lines in mice; Discussion; Macrophages: modulators of breast cancer progression; Discussion; Chemokines: angiogenesis and metastases in lung cancer; Discussion; Macrophage infiltration and angiogenesis in human malignancy; Discussion; The role of inflammation in tumour growth and tumour suppression; Discussion; Cyclooxygenase 2: from inflammation to carcinogenesis; DiscussionThe inflammatory cytokine network of epithelial cancer: therapeutic implications; Discussion; In vivo manipulation of DC migration and activation to elicit anti-tumour immunity; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject index
• Sommario/riassunto: Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems.Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subv