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Record Nr. |
UNINA9911018808403321 |
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Autore |
Ellenberg Susan Smith |
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Titolo |
Data monitoring committees in clinical trials : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets |
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Pubbl/distr/stampa |
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Chichester ; ; Hoboken, NJ, : Wiley, c2002 |
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ISBN |
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9786610269990 |
9781280269998 |
1280269995 |
9780470322284 |
0470322284 |
9780470854150 |
0470854154 |
9780470854167 |
0470854162 |
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Descrizione fisica |
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1 online resource (209 p.) |
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Collana |
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Altri autori (Persone) |
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FlemingThomas R |
DeMetsDavid L. <1944-> |
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Disciplina |
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Soggetti |
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Clinical trials |
Medical ethics committees |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Data Monitoring Committees in Clinical Trials A Practical Perspective; Contents; Preface; 1 Introduction; 1.1 Motivation; 1.2 History of data monitoring committees in government-sponsored trials; 1.3 Data monitoring committees in trials sponsored by the pharmaceutical industry; 1.4 Statistical methods for interim monitoring; 1.5 When are data monitoring committees needed?; 1.6 Where we are today; 1.7 Fundamental principles of data monitoring; References; 2 Responsibilities of the data monitoring committee and motivating illustrations; 2.1 Fundamental charges |
2.2 Specific tasks of the data monitoring committee 2.2.1 Initial review; 2.2.1.1 Review of the study protocol; 2.2.1.2 Review of procedures to |
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ensure quality of study conduct; 2.2.2 Evaluating the quality of ongoing study conduct; 2.2.3 Assessing safety and efficacy data; 2.2.3.1 Termination due to favorable benefit-to-risk; 2.2.3.2 Termination due to unfavorable benefit-to-risk; 2.2.3.3 Termination due to inability to answer trial questions; 2.2.3.4 Continuation of ongoing clinical trials; 2.2.3.5 Consideration of the overall picture: primary and secondary analyses |
2.2.3.6 Modifying sample sizes based on ongoing assessment of event rates 2.2.4 Reviewing the final results; 2.3 The data monitoring committee charter; References; 3 Composition of a data monitoring committee; 3.1 Introduction; 3.2 Required areas of expertise; 3.3 Other relevant characteristics of committee members; 3.4 Committee size; 3.5 Selecting the committee chair; 3.6 Responsibility for appointing committee members; 3.7 Representation of other study components on the committee; 3.8 Preparation for service on a committee; References |
4 Independence of the data monitoring committee: avoiding conflicts of interest 4.1 Introduction; 4.2 Rationale for independence; 4.3 Financial independence; 4.3.1 Sponsors; 4.3.2 Academic investigators; 4.4 Intellectual independence; 4.5 Emotional conflicts; 4.6 Individuals without conflicts; References; 5 Confidentiality issues relating to the data monitoring committee; 5.1 Rationale; 5.2 Limits of confidentiality; 5.2.1 Interim analysis reports; 5.2.2 Access to aggregate data on efficacy and safety outcomes; 5.2.3 The steering committee and maintaining confidentiality |
5.2.4 Settings and procedures allowing broader unblinding 5.2.5 Some illustrations of broader unblinding; 5.2.6 Indirect challenges to confidentiality; 5.3 The need for the data monitoring committee to review unblinded data; References; 6 Data monitoring committee meetings; 6.1 Introduction; 6.2 Specific objectives and timing of meetings; 6.2.1 Organizational meeting; 6.2.2 Early safety/trial integrity reviews; 6.2.3 Formal interim efficacy analyses; 6.2.4 End-of-trial debriefing; 6.3 Preparation of meeting reports; 6.4 Format for meetings; 6.4.1 The closed session; 6.4.2 The open session |
6.4.3 The final closed session |
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Sommario/riassunto |
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There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities.* Provides a practical overview of data monitoring in clinical trials.* |
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2. |
Record Nr. |
UNINA9911018791303321 |
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Autore |
Lee Robert T. H |
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Titolo |
Timing solutions for swing traders : successful trading using technical analysis and financial astrology / / Robert T.H. Lee, Peter A. Tryde |
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Pubbl/distr/stampa |
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Singapore, : John Wiley & Sons Singapore Pte. Ltd., c2012 |
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ISBN |
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9786613808493 |
9781119199045 |
1119199042 |
9781282165199 |
1282165194 |
9781118339183 |
1118339185 |
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Edizione |
[1st edition] |
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Descrizione fisica |
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1 online resource (210 p.) |
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Collana |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Stocks |
Speculation |
Technical analysis (Investment analysis) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Timing Solutions for Swing Traders: Successful Trading Using Technical Analysis and Financial Astrology; Contents; Foreword; Preface; Disclaimer; Chapter 1: Be Prepared; Fundamental and Technical Analysis; Conclusion; Chapter 2: Let's Get Started; Patterns; Volume; Price Momentum; Price and Moving Averages; Combining the Four Dimensions; Beyond Technical Analysis; Financial Astrology; Keeping Count; Conclusion; Chapter 3: Essential Patterns; Open; High; Low; Close; Candlestick Patterns; Divergence Patterns; Diagonal Patterns; Patterns Continued; ""M"" and ""W"" Patterns |
Head and Shoulders PatternsRectangle Patterns; Saucer Patterns; AB=CD Patterns; Gaps; Conclusion; Chapter 4: Elliott Waves; Wave 1; Wave 2; Wave 3; Wave 4; Wave 5; Extended Waves; Three-Wave |
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Structures; Corrective 3-3-5 Patterns; Flats; Irregular Flats; Corrective 5-3-5 Patterns; Zigzags; Complex Corrections; Triangles; Rule of Alternation; Fibonacci Retracement and Projection; Application of Elliott Wave Analysis; Conclusion; Appendix: Ratios and Wave Relationship; Chapter 5: Volume; Basic Volume Plots; Reading Volume; Money-Flow Indicator; Deciphering Trend with Volume; Conclusion |
Chapter 6: Key IndicatorsMomentum Oscillator; Queuing Theory of Moving Average Crossovers (QMAC); MACD; Average Direction Index; Protective Stops; Conclusion; Chapter 7: Applied Systems; Catching That Trend; Built-In Color Trend Indicator; Supporting Moving Averages; Trade on Daily Signals; Trading with Ichimoku; Conclusion; Chapter 8: Formulating Your Trading Plan; Determining Your Time Frame; Selecting Stocks; Risk Management; Determine Entry Points; Determine Exit Strategies; Reality Check; Chapter 9: Financial Astrology; Using Lunar Cycles in Trading; How to Pick Winning Stocks |
Choosing the Best Periods for TradingMarket Projection; Conclusion; Appendix 1: Ruling Planets of the Natural Horoscope; Appendix 2: Effects of Various Aspects; Appendix 3: Characteristics of the Twelve Zodiac Signs; Appendix 4: Formulas in MetaStock Format*; Momentum Timing Oscillator as Used in Figure 2.3; Volume Zone Oscillator as Referred to in Figure 2.10 and Figure 5.8; Volume Ratio Compressed Indicator as Referred to in Figure 5.3; Moving Average Line with Upper and Lower Mirror Lines as Referred to in Figure 7.8; Mid-Term Period Moving Average Lines as Referred to in Figure 2.5 |
GlossaryAstrological Terms; Bibliography; Suggested Reading; Astrological Books; Charting Software Programs; Astrology Software Programs; Financial Astrology Software Programs; Other Resources; About the Authors; Index |
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Sommario/riassunto |
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A unique new approach to trading based on financial analysis and financial astrology Timing Solutions for Swing Traders: Successful Trading Using Technical Analysis and Financial Astrology is a remarkable new book that introduces a revolutionary approach to non-day trading that combines the four basic dimensions of trend analysis-price patterns, volume, price momentum, and price moving averages-with a little financial astrology. Focusing on the essentials of technical analysis, the book is filled with examples of reliable indicators and formulas that traders can use to help dev |
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