The world of nano-biomechanics : mechanical imaging and measurement by atomic force microscopy / / Atsushi Ikai ; with contributions of R. Afrin, [et. al.]

• Record Nr.: UNINA9911006631603321
• Autore: Ikai Atsushi
• Pubbl/distr/stampa: Amsterdam ; ; Oxford, : Elsevier, 2008
• ISBN: 1-281-09627-X; 9786611096274; 0-08-055604-3
• Descrizione fisica: 1 online resource (301 p.)
• Disciplina: 502.82; 571.43
• Soggetti: Biomechanics; Nanostructures; Atomic force microscopy
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front Cover; The World of Nano-Biomechanics; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1. Force in Biology; 1.1 What are We Made of?; 1.2 Human Body and Force; 1.3 Biomechanics as the Big Brother; 1.4 Molecular Basis for Structural Design; 1.5 Soft versus Hard Materials; 1.6 Biological and Biomimetic Structural Materials; 1.7 Wear and Tear of Biological Structures; 1.8 Thermodynamics and Mechanics in Nanometer Scale Biology; Bibliography; Chapter 2. Introduction to Basic Mechanics; 2.1 Elastic and Plastic Deformation of Materials; 2.2 Stress and Strain Relationship; 2.3 Mechanical Breakdown of Materials2.4 Viscoelasticity; 2.5 Mechanical Moduli of Biological Materials; 2.6 Fluid and Viscosity; 2.7 Adhesion and Friction; 2.8 Mechanically Controlled Systems; Bibliography; Chapter 3. Force and Force Measurement Apparatuses; 3.1 Mechanical, Thermal, and Chemical Forces; 3.2 Laser Trap; 3.3 Atomic Force Microscope; 3.4 Biomembrane Force Probe; 3.5 Magnetic Beads; 3.6 Gel Columns; 3.7 Cantilever Force Sensors; 3.8 Loading-rate Dependence; 3.9 Force Clamp Method; 3.10 Specific versus Nonspecific ; Forces; Bibliography; Chapter 4. Polymer Chain Mechanics; 4.1 Polymers in Biological World4.2 Polymer Chains; 4.3 End-to-End Distance; 4.4 Persistence Length; 4.5 Polymers in Solution; 4.6 Polymers on the Surface; 4.7 Polymers as Biomimetic Materials; 4.8 Polymer Pull-out; Bibliography; Chapter 5. Interaction Forces; 5.1 Covalent versus Noncovalent Force; 5.2 Basics of Electrostatic Interaction Force; 5.3 Various Types of Noncovalent Forces; 5.4 Application of External Force; 5.5 Interaction Force Between Macromolecules; 5.6 Water at the Interface; Bibliography; Chapter 6. Single-Molecular Interaction Forces; 6.1 Ligand-receptor Interactions; 6.2 Sugar-lectin Interactions6.3 Antigen-antibody Interactions; 6.4 GroEL and Unfolded-Protein Interactions; 6.5 Lipid-protein Interactions; 6.6 Anchoring Force of Proteins to the Membrane; 6.7 Receptor Mapping; 6.8 Protein Unanchoring and Identification; 6.9 Membrane Breaking; Bibliography; Chapter 7. Single-molecule DNA and RNA Mechanics; 7.1 Stretching of Double-stranded DNA; 7.2 Hybridization and Mechanical Force; 7.3 Chain Dynamics and Transition of DNA and RNA; 7.4 DNA-protein Interaction; 7.5 Prospect for Sequence Analysis; Bibliography; Chapter 8. Single-molecule Protein Mechanics; 8.1 Protein-stretching Experiments8.2 Intramolecular Cores; 8.3 Stretching of Modular Proteins; 8.4 Dynamic Stretching; 8.5 Catch Bond; 8.6 Protein-compression Experiments; 8.7 Internal Mechanics of Protein Molecules; 8.8 Mechanical Control of Protein Activity; 8.9 Computer Simulation of Protein Deformation; Case Study: Carbonic Anhydrase II; Bibliography; Chapter 9. Motion in Nano-biology; 9.1 Cell Movement and Structural Proteins; 9.2 Muscle and Motor Proteins; 9.3 Single-motor Measurements; 9.4 Flagella for Bacterial Locomotion; 9.5 Mycoplasma Gliding; 9.6 Mechanics and Efficiency of Motor Proteins
• Sommario/riassunto: By using nanotechnological methods, we can now poke around protein molecules, genes, membranes, cells and more. Observation of such entities through optical and electron microscopes tempt us to touch and manipulate them. It is now possible to do so, and scientists around the world have started pulling, pushing and cutting small structures at the base of life processes to understand the effect of our hand work.The book describes the physical properties of such life supporting structures from the molecular level with a special emphasis on their designs based on the mechanical strength an