Risk to the thyroid from ionizing radiation [[electronic resource]]

• Record Nr.: UNINA9911006612903321
• Pubbl/distr/stampa: Bethesda, Md., : National Council on Radiation Protection and Measurements, 2009
• ISBN: 1-61583-010-3
• Descrizione fisica: 1 online resource (559 p.)
• Collana: NCRP report ; ; no. 159
• Disciplina: 362.196/9897
• Soggetti: Thyroid gland - Cancer - Etiology; Ionizing radiation - Toxicology; Ionizing radiation - Dose-response relationship
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Extensive update and expansion of: Induction of thyroid cancer by ionizing radiation. c1985.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: ""Preface""; ""Contents""; ""Executive Summary""; ""Purpose and Rationale""; ""Goals""; ""Synopsis of this Report""; ""Synopsis of this Reportâ€?s Conclusions and Recommendations""; ""Conclusions""; ""Recommendations""; ""1. Introduction""; ""1.1 Historic Overview""; ""1.1.1 Radioiodine Production and Use in the Study of Thyroid Physiology""; ""1.1.2 Use of Radioiodine in Medical Treatment""; ""1.1.3 Radiation Effects on the Thyroid Observed in Patients""; ""1.1.4 Radioiodine in the Environment""; ""1.2 Overview of this Report""; ""1.2.1 Thyroid and Parathyroid Glands""; ""1.2.2 Radiation Dosimetry and Dose Reconstruction""""1.2.3 Radiation Effects""; ""1.2.4 Radiation Risk for Thyroid Neoplasms""; ""1.2.5 Screening for Thyroid Disease Following Radiation Exposure""; ""1.2.6 Conclusions and Recommendations""; ""1.2.7 Appendices""; ""2. Thyroid and Parathyroid Glands""; ""2.1 Anatomy and Physiology""; ""2.1.1 Anatomy""; ""2.1.2 Physiology""; ""2.2 Diseases of the Thyroid and Parathyroid Glands""; ""2.2.1 Benign Thyroid Nodules""; ""2.2.2 Thyroid Cancer""; ""2.2.3 Functional Diseases""; ""2.3 Medical Uses of Radiation""; ""2.3.1 External Beam Radiation Therapy Exposures of the Thyroid""""2.3.2 Diagnostic Use of Radioactive Tracers in the Thyroid""; ""2.3.3 Radioactive Iodine Therapy""; ""2.3.4 Thyroid Dose from Radioactive ; Iodine""; ""2.4 Thyroid Genomics""; ""2.4.1 DNA Damage and Cellular Response""; ""2.4.2 Molecular Biology Techniques""; ""3. Radiation Dosimetry and Dose Reconstruction""; ""3.1 Specification of Dose in Principle and in Practice""; ""3.1.1 Specification of Dose: Ideal""; ""3.1.2 Specification of Dose: Practical""; ""3.2 External Dose""; ""3.2.1 Medical External Radiation Exposure""; ""3.2.2 External Radiation Exposure Associated with the Atomic Bombings of Hiroshima and Nagasaki""""3.3 Internal Dose""; ""3.3.1 Radioisotopes of Iodine""; ""3.3.2 Age-Dependent Thyroid Absorbed Doses from Radioisotopes of Iodine""; ""3.3.3 Environmental Dispersion of Radioiodine""; ""3.3.4 Potassium Iodide Blockade of Radioiodine Uptake in the Thyroid""; ""3.3.5 Limitations of the Radiobiological Significance of Iodine-129""; ""3.3.6 Spatial and Temporal Inhomogeneities in Intrathyroidal Radioiodine Distribution and Absorbed Dose""; ""3.3.7 Dose Assessment of Major Environmental Releases of Radioiodines""""3.4 Radiation Dosimetry in Specific Epidemiological Studies of Radiogenic Thyroid Disease""; ""4. Radiation Effects""; ""4.1 Animal Data""; ""4.1.1 Experiments with Rodents""; ""4.1.2 Experiments in Larger Animals""; ""4.1.3 Experiments to Determine Relative Biological Effectiveness""; ""4.2 Types of Epidemiologic Studies""; ""4.2.1 Cohort Studies""; ""4.2.2 Case-Control Studies""; ""4.2.3 Clinical Screening Studies""; ""4.2.4 Ecological (Aggregate) Studies""; ""4.3 Methodological Issues Regarding Studies of Radiation and Thyroid Tumors""