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Record Nr. |
UNISA996280372803316 |
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Titolo |
Algorithms and Architectures for Parallel Processing |
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Pubbl/distr/stampa |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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2. |
Record Nr. |
UNINA9910695363603321 |
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Autore |
Johnson Robert D (Robert David), <1974-> |
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Titolo |
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS [[electronic resource] ] : final report / / Robert D. Johnson, Russell J. Lewis |
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Pubbl/distr/stampa |
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Washington, DC : , : U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aerospace Medicine |
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[Ft. Belvoir, VA] : , : [Available through the Defense Technical Information Center] |
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Springfield, VA : , : Available through the National Technical Information Service, , [2005] |
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Descrizione fisica |
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i, 18 pages : digital, PDF file |
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Altri autori (Persone) |
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Soggetti |
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Adrenergic beta blockers - Analysis |
Aircraft accidents |
Hypertension - Treatment |
Propanolamines - Analysis |
Adrenergic beta-Antagonists - analysis |
Accidents, Aviation |
Aerospace Medicine - methods |
Chromatography, Liquid - methods |
Hypertension - drug therapy |
Mass Spectrometry - methods |
Technical Report |
United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from PDF t.p. (viewed May 24, 2006). |
"May 2005." |
"DOT/FAA/AM-05/10." |
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Nota di bibliografia |
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Includes bibliographical references (pages 6-7). |
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Sommario/riassunto |
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Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method. |
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3. |
Record Nr. |
UNINA9910984587203321 |
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Autore |
Hickey Anthony J |
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Titolo |
Pharmaceutical Powder and Particles / / by Anthony J. Hickey, Stefano Giovagnoli |
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Pubbl/distr/stampa |
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Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2025 |
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ISBN |
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Edizione |
[2nd ed. 2025.] |
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Descrizione fisica |
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1 online resource (167 pages) |
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Collana |
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AAPS Introductions in the Pharmaceutical Sciences, , 2522-8358 ; ; 60 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Pharmacology |
Pharmacy |
Drug delivery systems |
Drug Delivery |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- Importance of Finely Divided Solids in Pharmaceutical Dosage Forms -- Solid State Chemistry -- Crystallization -- Physical Properties -- Particle Size and Size Distribution -- Particle Size Characterization -- Fundamental of Particle Interactions -- Powder and Particle Dependent Traditional Manufacturing Processes (unit operations) -- Powder and Particle Dependent Biopharmaceutical Processes -- Recent and Evolving Manufacturing Processes -- Principles of Quality by Design -- General Discussion. |
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Sommario/riassunto |
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This book in the AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Hickey and Giovagnoli have written an essential book for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience, and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution; particle interaction; manufacturing processes; quality by design; and a |
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general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Innovation in manufacturing has expanded the range of options available for solid dosage form manufacture while continuing to rely on first principles of solid-state chemistry and characterization methods for powders and particles. In this new edition, the authors have expanded on existing chapters and added sections on new developments in the recent and evolving manufacturing processes including additive manufacturing technologies, controlled crystallization, spray-freeze-drying technology, and more. The editors have also comprehensively updated the references throughout the entire book. . |
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