The science of hormesis in health and longevity / / editors, Suresh I. S. Rattan, Marios Kyriazis

• Record Nr.: UNINA9910583040403321
• Pubbl/distr/stampa: London, United Kingdom : , : Academic Press, an imprint of Elsevier, , [2019]; ©2019
• ISBN: 0-12-814254-5
• Descrizione fisica: 1 online resource (327 pages)
• Disciplina: 615.7045
• Soggetti: Hormesis
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Front Cover -- The Science of Hormesis in Health and Longevity -- Copyright Page -- Contents -- List of Contributors -- Preface -- I. History, Terminology and Challenges -- 1 The Dose-Response Revolution: How Hormesis Became Significant: An Historical and Personal Reflection -- 1.1 Introduction -- 1.2 My Introduction to Hormesis -- 1.3 Preparing for Hormesis -- 1.4 The First Hormesis Conference -- 1.5 The BELLE Initiative and Hormesis -- 1.6 The Funding of Hormesis Research -- 1.7 Hormesis: Gaining Acceptance Within the Scientific Community -- 1.8 The Critiques-From the Constructive to the Pathological -- 1.9 Other Leaders of Hormesis Research -- 1.10 Don Luckey and Radiation Hormesis -- 1.11 Hormesis: Gaining Acceptance -- 1.12 Spreading the Hormesis Word -- 1.13 The Enemy Within -- 1.14 Rewriting Toxicological and Risk Assessment History -- 1.15 The Michigan State-Transgenerational Hormesis Story -- 1.16 Hormesis and Awards -- 1.17 Hormesis Research and Leadership Accomplishments -- 1.17.1 Research Accomplishments -- 1.17.2 Leadership Accomplishments -- 1.18 Final Thoughts: The Road Less Taken -- Conflict of Interest -- Acknowledgment -- References -- 2 Mild Stress-Induced Hormesis: Hopes and Challenges -- 2.1 Why to Use Hormesis in Prevention and Therapy? -- 2.2 How to Use Hormesis in Prevention and Therapy? -- 2.2.1 What Mild Stresses to Use? -- 2.2.2 What Age for a Mild Stress? ; -- 2.2.3 What Duration for a Mild Stress? -- 2.2.4 Individual Variability: Safety and Efficiency -- 2.3 Is It Possible to Mimic Hormesis? -- 2.4 Is It Useful to Combine Mild Stresses? -- 2.5 Hopes and Challenges for Therapy and Prevention -- 2.5.1 Using Mild Stress in Therapy -- 2.5.2 Using Mild Stress in Prevention -- 2.5.3 Qualifying Fasting as a Mild Stress for Therapy: An Ongoing Process -- 2.6 Conclusions -- References.; 3 Primary Stress Response Pathways for Preconditioning and Physiological Hormesis -- 3.1 Introduction -- 3.2 Heat Shock Response -- 3.2.1 HSF and Detection of Stress -- 3.2.2 HSP and Their Functional Role -- 3.2.3 HSR and Hormesis -- 3.3 Unfolded Protein Response -- 3.4 Oxidative Stress Response (OSR) -- 3.4.1 Regulation of Oxidative Stress -- 3.4.2 OSR and Hormesis -- 3.5 Hypoxia-Induced Stress Response (HISR) -- 3.6 DNA Damage Response -- 3.6.1 Detection and Repair of Double-Stranded DNA Breaks -- 3.7 Inflammatory Stress Response (ISR) -- 3.8 Energy Stress Response (ESR) -- 3.9 Nutritional Stress Response -- 3.10 Conclusions -- References -- II. Clinical and Lifestyle Hormesis -- 4 Remote Ischemic Conditioning as a Form of Hormesis -- 4.1 Introduction -- 4.2 Myocardial Infarct Size -- 4.3 Ischemic Preconditioning to Reduce Myocardial Infarct Size -- 4.4 Postconditioning to Reduce Myocardial Infarct Size -- 4.5 Remote Ischemic Conditioning to Reduce Myocardial Infarct Size -- 4.6 Other Applications of Remote Ischemic Conditioning -- 4.7 Conclusions -- References -- 5 Exercise and Hormesis -- 5.1 Introduction -- 5.2 Acute Adaptation to Exercise -- 5.3 The Effects of Regular Exercise on Housekeeping Pathways -- 5.4 Can Regular Exercise Attenuate the Aging Process? -- 5.4.1 Exercise and Neurodegenerative Diseases -- 5.4.2 Cardiovasular Diseases -- 5.4.3 Metabolic Diseases -- 5.4.4 Cancer -- 5.4.5 Sarcopenia -- 5.5 Conclusion -- References -- 6 Nutritional Hormesis in a Modern Environment -- 6.1 Introduction -- 6.2 Genetic Regulation of Aging -- 6.3 The Importance of Nutrition in Regulating the Aging Process -- 6.4 The Role of Good Nutrition for Health as We Age -- 6.5 The Diet, Hormesis, and Mitochondria -- 6.6 Oxidative Stress and Antioxidants -- 6.7 Dietary Sources of Hormetic Phytochemicals and Modulation of Age-Related Disease -- 6.7.1 Polyphenols.; 6.7.2 Carotenoids -- 6.7.3 Sulforaphane and Other Phytochemicals -- 6.8 Potential Mechanisms for Phytochemical Benefits in Aging -- 6.9 Bioavailability and Mechanisms of Cell uptake and Metabolism of Phytochemicals/Bioactive Compounds -- 6.10 Evidence for Molecular Damage Induced by Phytochemicals at Nontoxic Concentrations -- 6.11 Gaps and Opportunities -- References -- 7 Phyto-Hormetins in a Clinical Setting -- 7.1 Overview -- 7.2 Adaptive Nature of Hormesis: Phyto-Hormetins in the Animal and Human Diet -- 7.3 Hormesis Triggers and Biological CSRNs -- 7.4 Multitargeted Therapy and Nanoformulations of Phyto-Hormetins: Clinical Advantages and Implications for the Hormetic Do... -- 7.5 Summary and Conclusions -- References -- 8 Intermittent Fasting-Dietary Restriction as a Biological Hormetin for Health Benefits -- 8.1 Hormesis and Hormetins -- 8.2 Biological and Nutritional Hormetins -- 8.3 Dietary Restriction -- 8.4 Dietary Restriction as Hormetin -- 8.4.1 Beneficial Effects of Dietary Restriction -- 8.4.2 Dietary Restriction and Autophagy -- 8.4.3 Dietary Restriction and Neuroinflammation -- 8.5 Conclusion -- References -- 9 Hormetic Responses to Ethanol Ingestion: Focus on Moderation and Cardiovascular Protection -- 9.1 Introduction -- 9.2 Mechanisms of Cardiac Protection Induced by Ethanol Consumption -- 9.3 Protective Effects of Moderate Ethanol Ingestion in Stroke -- 9.4 Mitochondrial Aldehyde Dehydrogenase-2 Contributes to Ethanol-Induced Cardio- ; and Neuroprotection in Ischemia/Reperfusion -- 9.5 Ethanol Postconditioning Reduces Ischemia/Reperfusion Injury -- 9.6 Adaptive Cytoprotection in Splanchnic Organs After Ethanol Exposure -- 9.7 Ethanol Induces the Development of an Antiinflammatory Phenotype That Limits Postischemic Tissue Injury -- 9.8 Summary and Conclusions -- Acknowledgments -- References.; 10 Thermal Waters and the Hormetic Effects of Hydrogen Sulfide on Inflammatory Arthritis and Wound Healing -- 10.1 Introduction -- 10.2 Hydrogen Sulfide and Inflammatory Arthritis -- 10.3 Hydrogen Sulfide and Wound Healing -- 10.4 Conclusions -- Acknowledgment -- References -- III. Hormetic Stressors -- 11 Hormesis Through Low-Dose Radiation -- 11.1 Introduction -- 11.2 Potential Mechanisms Underlying Hormetic Effects -- 11.2.1 Activation of DNA Repair Pathways -- 11.2.2 Activation of Endogenous Antioxidant Systems -- 11.2.3 Induction of the Heat Shock Response -- 11.2.4 Apoptosis, Autophagy, and Compensatory Cell Proliferation -- 11.2.5 Stimulating Immune Response -- 11.3 Conclusions and Perspectives -- References -- 12 Metabolic Stress-Signaling and Metabolic Adaptation -- 12.1 Introduction -- 12.2 Nutrients and Nutrient-Sensing Pathways -- 12.3 Metabolic Intermediates as Transducers of Adaptive Responses -- 12.4 Adaptive Responses to Metabolic Stress -- 12.4.1 Metabolic Reprogramming -- 12.4.2 Epigenetic Regulation of Gene Transcription -- 12.4.3 Autophagy -- 12.4.4 Increased Metabolic Activity and Reactive Oxygen Species Formation -- 12.5 Metabolic Stress and Aging -- 12.6 Metabolic Stress and Cancer -- 12.7 Conclusion -- Acknowledgment -- References -- 13 DNA-Damage-Induced Hormetic Responses -- 13.1 Introduction -- 13.2 Genotoxic Stressors and Their Impact on the Organism -- 13.3 DNA-Damage Response -- 13.4 DNA-Repair Mechanisms and Cellular Response -- 13.5 Epigenetic Alterations and DNA Damage -- 13.6 DNA-Damage-Mediated Regulation of Autophagy, Inflammasome, and Cytokine Signaling -- 13.7 Hormetic Effects of DNA-Damage Response Modify Inflammatory Response -- 13.8 Hormesis Lessons From Caenorhabditis elegans -- 13.9 Radon Therapy in Immune System and Disease -- 13.10 Conclusion -- Acknowledgment -- References.; 14 Pathogen-Induced Hormetic Responses -- 14.1 Innate Immune Memory as a New Paradigm -- 14.2 Trained Resistance and Tolerance Responses Are Specified by Pathogen Dose -- 14.3 Molecular Signatures of Trained Immunity and Tolerance Responses -- 14.4 Medical Relevance -- 14.5 Conclusions -- References -- 15 Neuronal Stress and Its Hormetic Aspects -- 15.1 Introduction -- 15.2 Long-Term Depression -- 15.3 Long-Term Potentiation -- 15.4 Excitotoxicity -- References -- 16 Energetic Stress and Proteodynamics in Aging and Longevity -- 16.1 Introduction -- 16.2 Proteostasis is Complex, Dynamic, and Inherently Difficult to Assess -- 16.3 Cell Proliferation Provides Critical Context for Interpreting Protein Turnover: A Key Proteodynamic Mechanism -- 16.4 Energetic Stress, Proteodynamics, and Longevity -- 16.5 Proteostasis is Intertwined with the Other Pillars of Aging -- 16.6 Concluding Remarks -- References -- 17 Repeated Electromagnetic Field Stimulation in Aging and Health -- 17.1 Introduction -- 17.2 Repetitive Electromagnetic Field Shock and Biological Systems Interaction -- 17.3 Sources and Nature of Fields and Exposure -- 17.4 REMFS Hormetic Effect in Aging and Age-Related Diseases -- 17.4.1 REMFS Delays Cellular Senescence -- 17.4.2 REMFS Lowers Amyloid Beta in Primary Human Brain Cell Cultures -- 17.4.3 REMFS Improves Cognition in Alzheimer's Disease Mouse Models by Lowering Amyloid Beta Deposits -- 17.4.4 REMFS Future Clinical Application -- 17.4.4.1 REMFS to Delay Aging Process -- 17.4.4.2 ; REMFS to Treat Alzheimer's Disease and Other Protein Deposition Diseases -- 17.5 Conclusion -- References -- IV. Hormetic Interventions and Novel Perspectives -- 18 Hormesis for Healthy Aging -- 18.1 Introduction -- 18.2 Biological Basis of Aging -- 18.3 Hormetics and Hormetins -- 18.4 Thermal Hormesis -- 18.5 Exercise Hormesis -- 18.6 Radiation Hormesis.; 18.7 Calorie Restriction Hormesis.

American foreign policy since the Vietnam War : the search for consensus from Richard Nixon to George W. Bush / / Richard A. Melanson

• Record Nr.: UNINA9910973480503321
• Autore: Melanson Richard A.
• Pubbl/distr/stampa: London ; ; New York : , : Routledge, , 2015
• ISBN: 1-317-47719-7; 0-7656-1199-6; 1-315-70655-5; 1-317-47720-0
• Edizione: [Fourth edition.]
• Descrizione fisica: 1 online resource (432 p.)
• Disciplina: 327.73/009/045; 327.73009045
• Soggetti: United States Foreign relations 1945-1989; United States Foreign relations 1989-
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: First published 2005 by M.E. Sharpe.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: pt. 1. The rise and fall of the Cold War consensus -- part 2. American foreign policy after Vietnam -- part 3. The post-Cold War interlude -- part 4. The global war on terror -- part 5. Conclusions.
• Sommario/riassunto: This book integrates the study of presidential politics and foreign policy-making from the Vietnam aftermath to the events following September 11 and the Iraqi War. Focusing on the relationship between presidents' foreign policy agendas and domestic politics, it offers compelling portraits of presidents Nixon, Carter, Reagan, Bush I, Clinton, and Bush II. In the course of comparing the efforts of these ; presidents to articulate a clear conception of the national interest and to forge a foreign policy consensus, the author shows the key role of public opinion in constraining presidential initiate.