Live variola virus : considerations for continuing research / / Committee on the Assessment of Future Scientific Needs for Live Variola Virus; Board on Global Health ; Ann M. Arvin and Deepali M. Patel, editors ; Institute of Medicine of the National Academies

• Record Nr.: UNINA9910972731903321
• Pubbl/distr/stampa: Washington, D.C., : National Academies Press, 2009
• ISBN: 9786612412561; 9781282412569; 1282412566; 9780309136914; 0309136911
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (170 p.)
• Altri autori (Persone): ArvinAnn M; PatelDeepali
• Disciplina: 616.912
• Soggetti: Smallpox - Research; Smallpox - Prevention; Smallpox vaccine; Virology - Cultures and culture media
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: ""Reviewers""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Overview of Smallpox and Its Surveillance and Control""; ""3 Comparative Poxvirology""; ""4 Animal Models Using Variola and Other Orthopoxviruses""; ""5 Genomic Analysis""; ""6 Development of Therapeutics""; ""7 Development of Vaccines""; ""8 Methods for Detection and Diagnosis""; ""9 Discovery Research""; ""10 Conclusions and Recommendations""; ""Appendix: Variola Strains Used to Validate Diagnostic and Detection Assays""
• Sommario/riassunto: Smallpox was a devastating disease that decimated human populations for centuries, and its eradication in 1980 was a monumental achievement for the global health community. Since then the remaining known strains of its causative agent, variola virus, have been contained ; in two World Health Organization (WHO)-approved repositories. In 1999, the World Health Assembly (WHA) debated the issue of destroying these remaining strains. Arguments were presented on the need to retain the live virus for use in additional important research, and the decision to destroy the virus was deferred until this research could be completed. In that same year, the Institute of Medicine (IOM) convened a consensus committee to explore scientific needs for the live virus. In the ten years since the first IOM report, the scientific, political, and regulatory environments have changed. In this new climate, the IOM was once again tasked to consider scientific needs for live variola virus. The committee evaluated the scientific need for live variola virus in four areas: development of therapeutics, development of vaccines, genomic analysis, and discovery research.