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1. |
Record Nr. |
UNINA9910144448403321 |
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Titolo |
Pathway analysis for drug discovery [[electronic resource] ] : computational infrastructure and applications / / edited by Anton Yuryev |
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Pubbl/distr/stampa |
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Hoboken, N.J., : John Wiley & Sons, c2008 |
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ISBN |
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1-281-83126-3 |
9786611831264 |
0-470-39927-9 |
0-470-39926-0 |
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Descrizione fisica |
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1 online resource (332 p.) |
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Collana |
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Wiley series on technologies for the pharmaceutical industry |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Drug development - Data processing |
DNA microarrays - Data processing |
Computational biology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PATHWAY ANALYSIS FOR DRUG DISCOVERY; CONTENTS; Preface; Contributors; 1 Introduction to Pathway Analysis; 2 Software Infrastructure and Data Model for Pathway Analysis; 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks; 4 Algorithmic Basis for Pathway Visualization; 5 Pathway Analysis of High-Throughput Experimental Data; 6 Integrative Pathway Analysis of Disease Molecular Data; 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise; 8 Mammalian Proteome and Toxicant Network Analysis |
9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example10 Impact of Chemistry Information on Pathway Analysis; 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks; 12 An Adaptive System Model of the Yeast Glucose Sensor System; 13 Present and Future of Pathway Analysis in Drug Discovery; Index |
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Sommario/riassunto |
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This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in rela |
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2. |
Record Nr. |
UNINA9910972332303321 |
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Autore |
Tichi Cecelia <1942-> |
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Titolo |
Embodiment of a nation : human form in American places / / Cecelia Tichi |
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Pubbl/distr/stampa |
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Cambridge, Mass., : Harvard University Press, 2001 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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National characteristics, American |
Human body - Social aspects - United States - History |
Anthropomorphism |
Landscapes - United States - Psychological aspects - History |
Landscapes - Social aspects - United States - History |
Historic sites - United States |
United States Intellectual life |
United States History, Local |
United States Environmental conditions |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references (p. [272]-296) and index. |
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Nota di contenuto |
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Front matter -- Contents -- Illustrations -- Acknowledgments -- Introduction -- I Crania Americana -- 1 Mt. Rushmore: Heads of State and States of Heads -- 2 Walden Pond: Head Trips -- II Frontier |
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Incarnations -- 3 Pittsburgh at Yellowstone: Old Faithful and the Pulse of Industrial America -- 4 America’s Moon: “A Dream of the Future’s Face” -- III Bon Aqua -- 5 Hot Springs: American Hygeia -- 6 Love Canal: Hygeia’s Crisis -- Notes -- References -- Credits -- Index |
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Sommario/riassunto |
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From Harriet Beecher Stowe's image of the Mississippi's "bosom" to Henry David Thoreau's Cape Cod as "the bared and bended arm of Massachusetts," the American environment has been represented in terms of the human body. Exploring such instances of embodiment, Cecelia Tichi exposes the historically varied and often contrary geomorphic expression of a national paradigm. |
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