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Record Nr. |
UNINA9910261133303321 |
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Autore |
Ulrike C. Muller |
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Titolo |
The Physiological Functions of the Amyloid Precursor Protein Gene Family |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (275 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer's disease (AD), as proteolytical cleavage of APP gives rise to the Aß peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological functions of APP and the closely related APLPs is limited. This may have hampered our understanding of AD, since evidence has accumulated that not only the production of the Aß peptide but also the loss of APP-mediated functions may contribute to AD pathogenesis. Thus, it appears timely and highly relevant to elucidate the functions of the APP gene family from the molecular level to their role in the intact organism, i.e. in the context of nervous system development, synapse formation and adult synapse function, as well as neural homeostasis and aging. Why is our understanding of the APP functions so limited? APP and the APLPs are multifunctional proteins that undergo complex proteolytical processing. They give rise to an almost bewildering array of different fragments that may each subserve specific functions. While Aß is aggregation prone and neurotoxic, the large secreted ectodomain APPsa - produced in the non-amyloidogenic a-secretase pathway - has been shown to be neurotrophic, neuroprotective and relevant for synaptic plasticity, learning and memory. Recently, novel APP cleavage pathways and enzymes have been discovered that have gained much attention not only with respect to AD but also regarding their role in normal brain physiology. In addition to the various cleavage products, |
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there is also solid evidence that APP family proteins mediate important functions as transmembrane cell surface molecules, most notably in synaptic adhesion and cell surface signaling. Elucidating in more detail the molecular mechanisms underlying these divers functions thus calls for an interdisciplinary approach ranging from the structural level to the analysis in model organisms. Thus, in this research topic of Frontiers we compile reviews and original studies, covering our current knowledge of the physiological functions of this intriguing and medically important protein family. |
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2. |
Record Nr. |
UNINA9910971468803321 |
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Autore |
Kranen Annette |
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Titolo |
Historische Topographien : Bilder europäischer Reisender im Osmanischen Reich um 1700 / Annette Kranen, Klaus Krüger, Karin Gludovatz, Peter Geimer, Tobias Wendl, Christian Freigang, Jeong-hee Lee Kalisch |
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Pubbl/distr/stampa |
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Paderborn, : Brill | Fink, 2020 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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Collana |
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Berliner Schriften zur Kunst |
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Disciplina |
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Soggetti |
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Mobilität |
Reiseliteratur |
Archäologie |
Antikenrezeption |
transkulturell |
Stadtansichten |
Kartographie |
Mittelmeer |
mobility |
travelogue |
archaeology |
antiquarianism |
transcultural |
maps |
mediterranean |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Die Sicht Reisender aus Nordwesteuropa auf den östlichen Mittelmeerraum war um 1700 durch die Bibel und antike Quellen, die Kreuzzüge und die osmanische Herrschaft geprägt. Wie fanden diese historischen Schichten Eingang in das Bild der Region, das ihre Zeichnungen und illustrierten Berichte hervorbrachten? Reisende der Neuzeit fertigten Ansichten historischer Orte und Bauwerke im Osmanischen Reich für ein Publikum in Europa an. Diese Bilder wurden bislang meist als Quellen für die archäologische Forschung genutzt oder als Beleg für einen orientalistischen Blick gewertet. Die Studie beleuchtet sie erstmals in ihrem kulturhistorischen Kontext. Sie waren Teil eines breiten Austauschs über die Antike, für den auch der Kontakt mit lokalen Akteuren eine Rolle spielte. In drei Abschnitten zeigt das Buch auf, wie man das Reisen in die Länder der Bibel und der Antike verstand, wie man historisch bedeutende Topographien visualisierte und wie man sich Monumente und Relikte durch Zeichnen wie durch Sammeln aneignete. |
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