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1. |
Record Nr. |
UNINA9910970688203321 |
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Autore |
Anderson Neal G |
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Titolo |
Practical process research and development : a guide for organic chemists / / Neal G. Anderson |
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Pubbl/distr/stampa |
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Amsterdam ; ; Boston, : Academic Press, 2012 |
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ISBN |
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9781283735063 |
1283735067 |
9780123865380 |
0123865387 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (489 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Rev. ed. of: Practical process research & development. c2000. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Front Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY |
REFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS |
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III. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES |
Chapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS |
VII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS |
VI. TEMPERATURE CONTROL |
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Sommario/riassunto |
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"Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry"-- |
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2. |
Record Nr. |
UNINA9910965848303321 |
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Autore |
Collings Anthony |
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Titolo |
Capturing the news : three decades of reporting crisis and conflict / / by Anthony Collings |
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Pubbl/distr/stampa |
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Columbia, : University of Missouri Press, 2010 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (199 p.) |
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Disciplina |
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Soggetti |
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Journalists - United States |
Television journalists - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Intro -- Contents -- Acknowledgments -- Prologue Beirut 1981 -- Part I Overseas -- Chapter One No Building Collapsed -- Chapter Two Chr istmas Presents -- Chapter Three The Pope Has VD -- Chapter Four Line of Death -- Chapter Five Welcome to Tr ipoli -- Chapter Six Call the Palace -- Chapter Seven You Said That Yesterday -- Chapter Eight Two Endings -- Part II Washington -- Chapter Nine Face Down in the Mud -- Chapter Ten All the Earmarks -- Chapter Eleven Scoop -- Part III What's Wrong -- Chapter Twelve Dead Baby -- Chapter Thirteen Down, Down -- Chapter Fourteen Firewall -- Chapter Fifteen Only Time Will Tell -- Epilogue -- Notes -- Index. |
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Sommario/riassunto |
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Anthony Collings found himself in his share of difficult situations in his thirty-four years as a newsman. Like being captured by AK-47-toting Syrians in Lebanon in 1981 while looking for missiles that threatened a new outbreak of hostilities with Israel, or being "detained" by the KGB in Moscow in 1967 during his first foreign posting for the Associated Press filing stories about Soviet dissidents. Name a hot spot, and Collings has likely been there. From AP correspondent to Newsweek bureau chief to CNN reporter, he covered the Middle East, Rome, Moscow, London, Paris, and Washington. Now he has gathered stories about his work in a book that is both a journalist's memoir and a |
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commentary on the current ethical crises in the news media and how to address them. Brimming with entertaining stories about journalism, especially the chaotic early years at CNN when he and his colleagues established the first major cable news network, Collings's book reveals the dangers and pressures of covering the news and the difficulties of overcoming obstacles to the truth. He recalls smuggling tapes out of Poland after the Communists had imposed martial law; flying dangerously near Libya's "Line of Death"; interviewing world figures from Brezhnev to Kaddafi and Arafat; and winning awards for covering Iran-Contra and the Oklahoma City bombing. Collings brings fresh insights to the Oliver North affair and examines how the press was suckered in its coverage of the Jessica Lynch prisoner-of-war story in 2003. He voices his concerns regarding oversimplified reporting of complex issues and poses provocative questions about covering terrorism. In this book, Collings presents an insider's appraisal of the American news media's failings and accomplishments. Easy to read, informative, and thoughtful, Capturing the News will enlighten general readers interested in how journalists cover current affairs, while offering newsmen food for thought about the craft and ethics of journalism. |
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