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Record Nr. |
UNINA9910970451303321 |
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Autore |
Leong Anthony S.-Y (Anthony Siew-Yin), <1945-2011.> |
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Titolo |
Quantitative immunohistology : problems and solutions / / Anthony S-Y Leong and Trishe Y-M Leong |
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Pubbl/distr/stampa |
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Hauppauge, N.Y., : Nova Science Publishers, 2010 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (82 p.) |
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Collana |
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Immunology and immune system disorders |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Diagnostic immunohistochemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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The immunohistological assay : a total test approach -- Pre-analytical variables : tissue preservation, transportation, fixation and tissue processing -- Analytical variables : antigen retrieval, antibodies, detection systems and controls -- Post-analytical phase -- Receptor detection for targeted therapies -- Interobserver variability in quantitative immunohistology. |
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Sommario/riassunto |
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As immunohistochemistry enters its fourth decade as a diagnostic tool, this analytical procedure continues to experience poor reproducibility, albeit in specific situations. The problem becomes more important with the mounting pressure to employ the assay in a quantitative manner for the assessment of therapeutic and prognostic markers in a number of neoplasms. Qualitative applications of immunohistochemistry are well established and continue to increase with the range of sensitive antibodies and detection systems available, however, numerous variables that influence the immunoexpression of proteins in formalin-fixed tissue continue to exist in the pre-analytical and analytical phases of the test procedure. This book emphasizes these problems in detail and suggests possible solutions. |
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